Abstract：
Nasopharyngeal carcinoma (NPC) is closely related to Epstein-Barr virus (EBV) infection, and glycosylation of proteins is associated with precancerous lesions and carcinogenesis of NPC, and viral glycoproteins mediates the fusion of viruses with B cells or epithelial cells in the infection stage, promoting the conversion of normal epithelial cells into cancer cells. In the process of occurrence and development of NPC, various glycoproteins in the body promote or inhibit the proliferation, invasion, metastasis, and drug resistance of tumor cells, such as the tumor inhibitory effect of NGX6 and inhibin B (INHBB); the cancer-promoting effect of tenascin-C (TNC), fibronectin 1 (FN1), insulin-like growth factor binding protein-3 (IGFBP3), serglycin, and its core protein; and some effects of glycosylation of immune proteins on immunotherapy in NPC. This article provides an overview of the research progress on the interaction of glycoproteins associated with EBV infection with the occurrence and development of NPC.
摘要：
鼻咽癌与EB病毒(EBV)感染密切相关,蛋白质的糖基化与NPC的癌前病变和癌变有关，病毒糖蛋白在感染阶段介导病毒与B细胞或上皮细胞的融合，促进正常上皮细胞转化为癌细胞。在NPC的发生发展过程中,体内的各种糖蛋白促进或抑制增殖，入侵,转移,和肿瘤细胞的耐药性，如NGX6和抑制素B（INHBB）的肿瘤抑制作用；生腱蛋白C（TNC）的促癌作用，纤连蛋白1（FN1），胰岛素样生长因子结合蛋白-3（IGFBP3），serglycin,及其核心蛋白；免疫蛋白糖基化对鼻咽癌免疫治疗的一些影响。本文就EBV感染相关糖蛋白与鼻咽癌发生发展相互作用的研究进展作一综述。
