PDF(Pubmed)
Abstract：
Recognising the growing global burden of fungal infections, the World Health Organization (WHO) established an advisory group consisting of experts in fungal diseases to develop a Fungal Priority Pathogen List. Pathogens were ranked based on their research and development needs and perceived public health importance using a series of global surveys and pathogen characteristics derived from systematic reviews. This systematic review evaluates the features and global impact of invasive disease caused by Candida glabrata (Nakaseomyces glabrata). PubMed and Web of Science were searched for studies reporting on mortality, morbidity (hospitalization and disability), drug resistance (including isolates from sterile and non-sterile sites, since these reflect the same organisms causing invasive infections), preventability, yearly incidence, diagnostics, treatability, and distribution/emergence in the last 10 years. Candida glabrata (N. glabrata) causes difficult-to-treat invasive infections, particularly in patients with underlying conditions such as immunodeficiency, diabetes, or those who have received broad-spectrum antibiotics or chemotherapy. Beyond standard infection prevention and control measures, no specific preventative measures have been described. We found that infection is associated with high mortality rates and that there is a lack of data on complications and sequelae. Resistance to azoles is common and well described in echinocandins-in both cases, the resistance rates are increasing. Candida glabrata remains mostly susceptible to amphotericin and flucytosine. However, the incidence of the disease is increasing, both at the population level and as a proportion of all invasive yeast infections, and the increases appear related to the use of antifungal agents.
摘要：
认识到真菌感染的全球负担日益增加，世界卫生组织（WHO）成立了一个由真菌病专家组成的咨询小组，以制定真菌优先病原体清单。使用一系列全球调查和系统评价得出的病原体特征，根据其研究和开发需求以及对公共卫生的重要性对病原体进行了排名。本系统综述评估了光滑念珠菌（Nakaseomycesglabrata）引起的侵袭性疾病的特征和全球影响。搜索了PubMed和WebofScience报告死亡率的研究，发病率（住院和残疾），耐药性（包括无菌和非无菌部位的分离株，因为这些反映了导致侵入性感染的相同生物体)，可预防性,年发病率，诊断,可治疗性，以及过去10年的分布/出现。光滑念珠菌(N.glabrata)导致难以治疗的侵入性感染，特别是在患有潜在疾病如免疫缺陷的患者中，糖尿病,或接受过广谱抗生素或化疗的人。超出标准的感染预防和控制措施，没有描述具体的预防措施。我们发现感染与高死亡率相关，并且缺乏有关并发症和后遗症的数据。在棘白菌素中，对唑类的耐药性是常见的，并且在这两种情况下都有很好的描述，阻力率正在增加。光滑念珠菌仍然对两性霉素和氟胞嘧啶最敏感。然而,这种疾病的发病率正在增加，无论是在人口水平还是在所有侵袭性酵母菌感染中的比例，增加似乎与抗真菌药物的使用有关。
