PDF(Pubmed)
Abstract：
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal pathogen priority list. This systematic review aimed to evaluate the epidemiology and impact of infections caused by Talaromyces marneffei, Coccidioides species, and Paracoccidioides species. PubMed and Web of Sciences databases were searched to identify studies published between 1 January 2011 and 23 February 2021 reporting on mortality, complications and sequelae, antifungal susceptibility, preventability, annual incidence, and trends. Overall, 25, 17, and 6 articles were included for T. marneffei, Coccidioides spp. and Paracoccidioides spp., respectively. Mortality rates were high in those with invasive talaromycosis and paracoccidioidomycosis (up to 21% and 22.7%, respectively). Hospitalization was frequent in those with coccidioidomycosis (up to 84%), and while the duration was short (mean/median 3-7 days), readmission was common (38%). Reduced susceptibility to fluconazole and echinocandins was observed for T. marneffei and Coccidioides spp., whereas >88% of T. marneffei isolates had minimum inhibitory concentration values ≤0.015 μg/ml for itraconazole, posaconazole, and voriconazole. Risk factors for mortality in those with talaromycosis included low CD4 counts (odds ratio 2.90 when CD4 count <200 cells/μl compared with 24.26 when CD4 count <50 cells/μl). Outbreaks of coccidioidomycosis and paracoccidioidomycosis were associated with construction work (relative risk 4.4-210.6 and 5.7-times increase, respectively). In the United States of America, cases of coccidioidomycosis increased between 2014 and 2017 (from 8232 to 14 364/year). National and global surveillance as well as more detailed studies to better define sequelae, risk factors, outcomes, global distribution, and trends are required.
摘要：
世界卫生组织,为了应对日益增长的真菌疾病负担，建立了制定真菌病原体优先级列表的过程。本系统评价旨在评估马尔尼菲塔拉菌感染的流行病学和影响。球虫物种，和副球菌物种。搜索PubMed和WebofSciences数据库，以确定2011年1月1日至2021年2月23日期间发表的报告死亡率的研究。并发症和后遗症，抗真菌药敏,可预防性,年发病率,和趋势。总的来说,包括25、17和6篇文章，球虫属。和副球菌属。,分别。侵袭性距真菌病和副角菌病的死亡率很高（高达21％和22.7％，分别)。球孢子菌病患者住院频繁（高达84%），虽然持续时间短（平均/中位数3-7天），再入院很常见(38%)。观察到马尔尼菲和球藻对氟康唑和棘白菌素的敏感性降低。,而>88%的马尔尼菲分离株对伊曲康唑的最小抑制浓度值≤0.015μg/ml，泊沙康唑,和伏立康唑.塔拉真菌病患者死亡的危险因素包括CD4计数低（当CD4计数<200个细胞/μ1时，比值比为2.90，而当CD4计数<50个细胞/μ1时，比值比为24.26）。球孢子菌病和副球孢子菌病的爆发与建筑工作有关（相对风险增加4.4-210.6和5.7倍，分别)。在美利坚合众国,2014年至2017年期间球孢子菌病病例有所增加(从8232例至14364例/年).国家和全球监测以及更详细的研究，以更好地定义后遗症，危险因素，结果，全球分销,趋势是必需的。
