Abstract：
Centrosomes are dominant microtubule organizing centers in animal cells with a pair of centrioles at their core. They template cilia during interphase and help organize the mitotic spindle for a more efficient cell division. Here, we review the roles of centrosomes in the early developing mouse and during organ formation. Mammalian cells respond to centrosome loss-of-function by activating the mitotic surveillance pathway, a timing mechanism that, when a defined mitotic duration is exceeded, leads to p53-dependent cell death in the descendants. Mouse embryos without centrioles are highly susceptible to this pathway and undergo embryonic arrest at mid-gestation. The complete loss of the centriolar core results in earlier and more severe phenotypes than that of other centrosomal proteins. Finally, different developing tissues possess varying thresholds and mount graded responses to the loss of centrioles that go beyond the germ layer of origin.
摘要：
中心体是动物细胞中主要的微管组织中心，核心有一对中心体。它们在间期为纤毛模板，并帮助组织有丝分裂纺锤体，以实现更有效的细胞分裂。这里,我们回顾了中心体在早期发育小鼠和器官形成过程中的作用。哺乳动物细胞通过激活有丝分裂监测途径对中心体功能丧失作出反应，一种定时机制，当超过定义的有丝分裂持续时间时，导致后代p53依赖性细胞死亡。没有中心粒的小鼠胚胎对该途径高度敏感，并在妊娠中期经历胚胎停滞。与其他中心体蛋白相比，中心体核心的完全丧失导致更早和更严重的表型。最后,不同的发育组织具有不同的阈值，并对超出原始胚层的中心粒损失产生分级反应。
