Abstract：
UNASSIGNED: Influenza affects individuals of all ages and poses a significant threat during pandemics, epidemics, and sporadic outbreaks. Neuraminidase inhibitors (NAIs) are currently the first choice in the treatment and prevention of influenza, but their use can be hindered by viral resistance.
UNASSIGNED: This review summarizes current NAIs pharmacological profiles, their current place in therapy, and the mechanisms of viral resistance and outlines possible new indications, ways of administration, and novel candidate NAIs compounds.
UNASSIGNED: NAIs represent a versatile group of compounds with diverse administration methods and pharmacokinetics. While the prevalence of influenza virus resistance to NAIs remains low, there is heightened vigilance due to the pandemic potential of influenza. Several novel NAIs and derivatives are currently under assessment at various stages of development for the treatment and prevention of influenza.
UNASSIGNED: This review summarizes current NAIs pharmacological profiles, their current place in therapy, and the mechanisms of viral resistance and outlines possible new indications, ways of administration, and novel candidate NAIs compounds.
UNASSIGNED: NAIs represent a versatile group of compounds with diverse administration methods and pharmacokinetics. While the prevalence of influenza virus resistance to NAIs remains low, there is heightened vigilance due to the pandemic potential of influenza. Several novel NAIs and derivatives are currently under assessment at various stages of development for the treatment and prevention of influenza.
摘要：
■流感影响所有年龄的个体，并在大流行期间构成重大威胁，流行病,和零星爆发。神经氨酸酶抑制剂（NAIs）是目前治疗和预防流感的首选药物，但是它们的使用可能会受到病毒抗性的阻碍。
■这篇综述总结了当前的NAIs药理学概况，他们目前在治疗中的地位，以及病毒抗性的机制，并概述了可能的新适应症，管理方式,和新的候选NAIs化合物。
■NAIs代表具有不同给药方法和药代动力学的通用化合物组。尽管流感病毒对NAI的耐药性仍然很低，由于流感的大流行潜力，人们提高警惕。目前正在评估几种新的NAI和衍生物用于治疗和预防流感的不同开发阶段。
■这篇综述总结了当前的NAIs药理学概况，他们目前在治疗中的地位，以及病毒抗性的机制，并概述了可能的新适应症，管理方式,和新的候选NAIs化合物。
■NAIs代表具有不同给药方法和药代动力学的通用化合物组。尽管流感病毒对NAI的耐药性仍然很低，由于流感的大流行潜力，人们提高警惕。目前正在评估几种新的NAI和衍生物用于治疗和预防流感的不同开发阶段。
