PDF(Pubmed)
Abstract：
UNASSIGNED: Changes in brain structural connections appear to be important in the pathophysiology of substance use disorders, but their role in behavioral addictions, such as gambling disorder (GD), is unclear. GD also offers a model to study addiction mechanisms without pharmacological confounding factors. Here, we used multimodal MRI data to examine the integrity of white matter connections in individuals with GD. We hypothesized that the affected areas would be in the fronto-striatal-thalamic circuit.
UNASSIGNED: Twenty individuals with GD (mean age: 64 years, GD duration: 15.7 years) and 40 age- and sex-matched healthy controls (HCs) underwent detailed clinical examinations together with brain 3T MRI scans (T1, T2, FLAIR and DWI). White matter (WM) analysis involved fractional anisotropy and lesion load, while gray matter (GM) analysis included voxel- and surface-based morphometry. These measures were compared between groups, and correlations with GD-related behavioral characteristics were examined.
UNASSIGNED: Individuals with GD showed reduced WM integrity in the left and right frontal parts of the corona radiata and corpus callosum (pFWE < 0.05). WM gambling symptom severity (SOGS score) was negatively associated to WM integrity in these areas within the left hemisphere (p < 0.05). Individuals with GD also exhibited higher WM lesion load in the left anterior corona radiata (pFWE < 0.05). GM volume in the left thalamus and GM thickness in the left orbitofrontal cortex were reduced in the GD group (pFWE < 0.05).
UNASSIGNED: Similar to substance addictions, the fronto-striatal-thalamic circuit is also affected in GD, suggesting that this circuitry may have a crucial role in addictions, independent of pharmacological substances.
UNASSIGNED: Twenty individuals with GD (mean age: 64 years, GD duration: 15.7 years) and 40 age- and sex-matched healthy controls (HCs) underwent detailed clinical examinations together with brain 3T MRI scans (T1, T2, FLAIR and DWI). White matter (WM) analysis involved fractional anisotropy and lesion load, while gray matter (GM) analysis included voxel- and surface-based morphometry. These measures were compared between groups, and correlations with GD-related behavioral characteristics were examined.
UNASSIGNED: Individuals with GD showed reduced WM integrity in the left and right frontal parts of the corona radiata and corpus callosum (pFWE < 0.05). WM gambling symptom severity (SOGS score) was negatively associated to WM integrity in these areas within the left hemisphere (p < 0.05). Individuals with GD also exhibited higher WM lesion load in the left anterior corona radiata (pFWE < 0.05). GM volume in the left thalamus and GM thickness in the left orbitofrontal cortex were reduced in the GD group (pFWE < 0.05).
UNASSIGNED: Similar to substance addictions, the fronto-striatal-thalamic circuit is also affected in GD, suggesting that this circuitry may have a crucial role in addictions, independent of pharmacological substances.
摘要：
■大脑结构连接的变化似乎在物质使用障碍的病理生理学中很重要，但是它们在行为成瘾中的作用，如赌博障碍(GD)，不清楚。GD还提供了一个模型来研究成瘾机制，而没有药理混杂因素。这里,我们使用多模态MRI数据检查GD患者白质连接的完整性.我们假设受影响的区域将在额叶-纹状体-丘脑回路中。
■20名GD患者（平均年龄：64岁，GD持续时间：15.7年）和40个年龄和性别匹配的健康对照（HCs）进行了详细的临床检查以及脑3TMRI扫描（T1，T2，FLAIR和DWI）。白质（WM）分析涉及分数各向异性和病变负荷，而灰质（GM）分析包括基于体素和表面的形态计量学。这些指标在组间进行了比较，并检查了与GD相关行为特征的相关性。
■患有GD的个体在放射状冠部和call体的左右额部显示出WM完整性降低（pFWE<0.05）。WM赌博症状严重程度（SOGS评分）与左半球这些区域的WM完整性呈负相关（p<0.05）。患有GD的个体在左前电晕辐射中也表现出更高的WM损伤负荷(pFWE<0.05)。GD组左侧丘脑GM体积和左眶额叶皮质GM厚度降低(pFWE<0.05)。
■类似于物质成瘾，在GD中，额-纹状体-丘脑回路也受到影响，这表明这种电路可能在成瘾中起着至关重要的作用，独立于药理物质。
■20名GD患者（平均年龄：64岁，GD持续时间：15.7年）和40个年龄和性别匹配的健康对照（HCs）进行了详细的临床检查以及脑3TMRI扫描（T1，T2，FLAIR和DWI）。白质（WM）分析涉及分数各向异性和病变负荷，而灰质（GM）分析包括基于体素和表面的形态计量学。这些指标在组间进行了比较，并检查了与GD相关行为特征的相关性。
■患有GD的个体在放射状冠部和call体的左右额部显示出WM完整性降低（pFWE<0.05）。WM赌博症状严重程度（SOGS评分）与左半球这些区域的WM完整性呈负相关（p<0.05）。患有GD的个体在左前电晕辐射中也表现出更高的WM损伤负荷(pFWE<0.05)。GD组左侧丘脑GM体积和左眶额叶皮质GM厚度降低(pFWE<0.05)。
■类似于物质成瘾，在GD中，额-纹状体-丘脑回路也受到影响，这表明这种电路可能在成瘾中起着至关重要的作用，独立于药理物质。
