Abstract：
In recent decades, the field of systemic cancer treatment has seen remarkable changes due to advancements in the understanding of cancer\'s biology, immunology, and genetic makeup. As a result, individuals with late-stage cancers are now achieving survival rates that were previously unattainable. The goal of personalized cancer therapy is to enhance clinical outcomes by customizing drug treatments to suit the unique genetic and/or epigenetic profiles of each patient\'s tumor. This approach aims to reduce the side effects commonly associated with ineffective treatments. Advances in genetic sequencing and molecular cytogenetics have been instrumental in identifying cancer-driving mutations and epigenetic irregularities, leading to the development of specific molecular therapies. This review article highlights the progress and success of targeted molecular therapies in treating malignant melanoma, illustrating the concept of personalized cancer treatment.
摘要：
近几十年来,由于对癌症生物学理解的进步，系统性癌症治疗领域发生了显著的变化，免疫学,和基因构成。因此,晚期癌症患者现在获得了以前无法达到的生存率。个性化癌症治疗的目标是通过定制药物治疗以适应每个患者肿瘤的独特遗传和/或表观遗传特征来提高临床结果。这种方法旨在减少通常与无效治疗相关的副作用。基因测序和分子细胞遗传学的进展有助于识别癌症驱动突变和表观遗传不规则性，导致特定分子疗法的发展。本文综述了靶向分子治疗恶性黑色素瘤的进展和成功。说明个性化癌症治疗的概念。
