Abstract：
OBJECTIVE: Parenteral nutrition (PN) can be an effective treatment to improve the nutritional status of patients with pancreatic cancer, but the effects of PN on quality of life (QoL) are still understudied. Therefore, we aimed at investigating whether the best supportive nutritional care (BSNC) in combination with PN at home compared to BSNC alone changed QoL in patients with advanced pancreatic cancer undergoing chemotherapy over a period of 7 weeks.
METHODS: n = 12 patients in the PANUSCO study received nutritional counseling only (control group (CG)) and n = 9 patients were also given supportive PN (intervention group (IG)). The primary endpoint was the change of QoL (EORTC-QLQ-C30 and QLQ-PAN26) over 7 weeks between the groups.
RESULTS: There was a significant worsening in social functioning in IG (p = 0.031) and a significant difference between groups in change of social functioning (p = 0.020). In all other domains of QoL, there was no significant difference between groups. Within groups, there was a significant improvement in the domain weight loss in IG (p = 0.031), showing that patients were less worried about their weight being too low. Furthermore, there was a significant difference in the change of BW over time between groups (p < 0.001) with IG showing an increase (p = 0.004) and CG showing no change (p = 0.578).
CONCLUSIONS: The administration of PN had in one of five domains negative consequences on QoL. The decision to administer PN should always be made individually and together with the patient, and the impact on QoL should be included in the decision to administer PN.
METHODS: n = 12 patients in the PANUSCO study received nutritional counseling only (control group (CG)) and n = 9 patients were also given supportive PN (intervention group (IG)). The primary endpoint was the change of QoL (EORTC-QLQ-C30 and QLQ-PAN26) over 7 weeks between the groups.
RESULTS: There was a significant worsening in social functioning in IG (p = 0.031) and a significant difference between groups in change of social functioning (p = 0.020). In all other domains of QoL, there was no significant difference between groups. Within groups, there was a significant improvement in the domain weight loss in IG (p = 0.031), showing that patients were less worried about their weight being too low. Furthermore, there was a significant difference in the change of BW over time between groups (p < 0.001) with IG showing an increase (p = 0.004) and CG showing no change (p = 0.578).
CONCLUSIONS: The administration of PN had in one of five domains negative consequences on QoL. The decision to administer PN should always be made individually and together with the patient, and the impact on QoL should be included in the decision to administer PN.
摘要：
目的：肠外营养（PN）可以成为改善胰腺癌患者营养状况的有效治疗方法。但PN对生活质量（QoL）的影响仍未得到充分研究。因此,我们的目的是调查在接受7周化疗的晚期胰腺癌患者中,与单独使用BSNC相比,家庭最佳支持性营养护理(BSNC)联合PN治疗是否能改变QoL.
方法：在PANUSCO研究中，n=12例患者仅接受了营养咨询（对照组（CG）），n=9例患者还接受了支持性PN（干预组（IG））。主要终点是7周内组间QoL(EORTC-QLQ-C30和QLQ-PAN26)的变化。
结果：IG的社会功能显着恶化（p=0.031），两组之间的社会功能变化存在显着差异（p=0.020）。在QoL的所有其他领域中，组间无显著差异。在群体中,IG的域失重有显著改善(p=0.031)，这表明患者不太担心自己的体重太低。此外，两组之间的BW随时间的变化存在显着差异（p<0.001），其中IG显示增加（p=0.004），CG显示无变化（p=0.578）。
结论：PN的管理在五个领域之一对QoL产生负面影响。给予PN的决定应始终与患者一起单独做出，对QoL的影响应包括在管理PN的决定中。
方法：在PANUSCO研究中，n=12例患者仅接受了营养咨询（对照组（CG）），n=9例患者还接受了支持性PN（干预组（IG））。主要终点是7周内组间QoL(EORTC-QLQ-C30和QLQ-PAN26)的变化。
结果：IG的社会功能显着恶化（p=0.031），两组之间的社会功能变化存在显着差异（p=0.020）。在QoL的所有其他领域中，组间无显著差异。在群体中,IG的域失重有显著改善(p=0.031)，这表明患者不太担心自己的体重太低。此外，两组之间的BW随时间的变化存在显着差异（p<0.001），其中IG显示增加（p=0.004），CG显示无变化（p=0.578）。
结论：PN的管理在五个领域之一对QoL产生负面影响。给予PN的决定应始终与患者一起单独做出，对QoL的影响应包括在管理PN的决定中。
