Abstract：
Butyrophilin (BTN) proteins are a type of membrane protein that belongs to the Ig superfamily. They exhibit a high degree of structural similarity to molecules in the B7 family. They fulfill a complex function in regulating immune responses, including immunomodulatory roles, as they influence γδ T cells. The biology of BTN molecules indicates that they are capable of inhibiting the immune system\'s ability to detect antigens within tumors. A dynamic association between BTN molecules and cellular surfaces is also recognized in specific contexts, influencing their biology. Notably, the dynamism of BTN3A1 is associated with the immunosuppression of T cells or the activation of Vγ9Vδ2 T cells. Cancer immunotherapy relies heavily on T cells to modulate immune function within the intricate interaction of the tumor microenvironment (TME). A significant interaction between the TME and antitumor immunity involves the presence of BTN, which should be taken into account when developing immunotherapy. This review explores potential therapeutic applications of BTN molecules, based on the current understanding of their biology.
摘要：
butyrophilin(BTN)蛋白是属于Ig超家族的一种膜蛋白。它们与B7家族中的分子表现出高度的结构相似性。它们在调节免疫反应方面具有复杂的功能，包括免疫调节作用,因为它们影响γδT细胞。BTN分子的生物学特性表明它们能够抑制免疫系统检测肿瘤内抗原的能力。BTN分子和细胞表面之间的动态关联在特定环境中也被识别。影响他们的生物学。值得注意的是,BTN3A1的动力学与T细胞的免疫抑制或Vγ9Vδ2T细胞的活化有关。癌症免疫疗法在很大程度上依赖于T细胞来调节肿瘤微环境(TME)的复杂相互作用内的免疫功能。TME和抗肿瘤免疫之间的显着相互作用涉及BTN的存在，在开发免疫疗法时应考虑到这一点。这篇综述探讨了BTN分子的潜在治疗应用，基于他们目前对生物学的理解。
