Abstract：
\'Structure determines function\' is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always limited the oral administration of peptides. Therefore, we analyze the main ways oral peptide conversion strategies of peptide modification and permeation enhancers. Based on our analysis of the structure of natural oral peptides, which can be absorbed through the gastrointestinal tract, we believe that the design strategy of natural stapled peptides based on disulfide bonds is good for oral peptide design. This cannot only be used to identify anti-gastrointestinal digestive structural proteins in nature but also provide a solid structural foundation for the construction of new oral peptide drugs.
摘要：
“结构决定功能”是当前生物界的共识，但是与某种功能相对应的结构特征一直是科学探索的热点领域。肽是介于抗体和小分子大小之间的生物活性分子。尽管如此，肽的胃肠屏障和理化性质一直限制了肽的口服给药。因此,分析了肽修饰和渗透增强剂口服肽转化策略的主要途径。根据我们对天然口服肽结构的分析，可以通过胃肠道吸收，我们认为，基于二硫键的天然装订肽的设计策略有利于口服肽的设计。这不仅可用于天然抗胃肠消化结构蛋白的鉴定,也为新型口服多肽药物的构建提供了坚实的结构基础。
