Abstract：
A phytochemical investigation on the 80% EtOH extract of the leaves of Paederia scandens (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-O-trans-p-coumaroyl-(4R,6R)-3,4-dihydro-3α-methylthiopaederoside (1), 10-O-trans-feruloyl-(4S,6R)-3,4-dihydro-2\'-O-3α-paederoside (2), and 10-O-trans-caffeoyl-paederosidic acid ethyl ester (3). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against five endocrine tumor cell lines. As a result, compound 1 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 20.0 μM.
摘要：
对赤霉病叶的80％EtOH提取物的植物化学研究（Lour。）合并。结果分离出三种未描述的环烯醚萜苷，10-O-反式-对-香豆酰基-(4R,6R)-3,4-二氢-3α-甲硫代松苷(1)，10-O-反式-阿魏酸-(4S，6R)-3,4-二氢-2'-O-3α-芍药苷(2)，和10-O-反式-咖啡酰基-紫藤酸乙酯(3)。通过1D和2D等光谱方法阐明了新化合物的结构（1H-1HCOSY，HMQC,和HMBC)核磁共振波谱，以及高分辨率质谱。在体外测试了分离的化合物对五种内分泌肿瘤细胞系的细胞毒性活性。因此,化合物1对所有测试的肿瘤细胞系表现出一定的细胞毒性,IC50值小于20.0μM。
