Abstract：
Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM\'s for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM\'s captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time. Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.
摘要：
骨关节炎（OA）导致膝盖内的骨形状变化。此外，发生OA的风险随着年龄的增长而增加。然而,年龄本身并不会导致OA。因此，在将这些变化归因于OA之前，了解与健康年龄相关的膝盖形状轨迹非常重要。这项研究的目的是使用统计形状建模（SSM）确定骨性膝盖形状与年龄之间的关联。96名参与者接受了膝盖的CT扫描。使用手动分割创建三维模型。为股骨远端和胫骨近端创建单独的SSM。线性回归模型用于评估年龄与股骨和胫骨形状之间的关联。股骨和胫骨SSM的十四种模式捕获了68%和73%的形状变化，分别。只有股骨模式3和胫骨模式7与年龄相关。年龄的增加与股骨骨量的增加和股骨滑车沟的加深有关。此外，年龄增加与胫骨平台内侧扩张有关。骨性股骨和胫骨的形状与衰老显著相关，包括股骨和胫骨的大小，股骨滑车沟，胫骨内侧平台区。膝关节形态的变化是正常的衰老过程，而没有骨关节炎的发展。这可以是随时间对机械负载的响应。进一步研究这些变化对膝关节负荷的影响可能为老年人的膝关节健康提供有价值的信息。
