PDF(Pubmed)
Abstract：
UNASSIGNED: The association of cognitive function, its changes, and all-cause mortality has not reached a consensus, and the independence of the association between changes in cognitive function and mortality remains unclear. The purpose of this study was to evaluate the longitudinal association between baseline cognitive function and cognitive changes over 1 year with subsequent all-cause mortality among the older adults aged 60 and above.
UNASSIGNED: A prospective cohort study utilizing the Community Older Adults Health Survey data. Initiated in 2018, the study annually assessed all individuals aged 60+ in Dalang Town, Dongguan City. Cognitive function was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). A total of 6,042 older adults individuals were included, and multivariate Cox proportional hazard models were used to examine cognitive function\'s impact on mortality.
UNASSIGNED: Participants\' median age was 70 years, with 39% men. Over a median 3.08-year follow-up, 525 died. Mortality risk increased by 6% per MMSE score decrease (adjusted HR = 1.06, 95%CI: 1.05-1.08). Compared to those with normal cognitive function at baseline, participants with mild cognitive impairment and moderate to severe cognitive impairment had significantly higher mortality risks (adjusted HR = 1.40, 95%CI: 1.07-1.82; HR = 2.49, 95%CI: 1.91-3.24, respectively). The risk of death was 5% higher for each one-point per year decrease in cognitive function change rate (HR = 1.05, 95%CI: 1.02-1.08). Compared with participants with stable cognitive function, those with rapid cognitive decline had a 79% increased risk of death (adjusted HR = 1.79, 95% CI: 1.11-2.87), with baseline cognitive function influencing this relationship significantly (P for interaction = 0.002).
UNASSIGNED: Baseline cognitive impairment and rapid cognitive decline are associated with higher all-cause mortality risks in Chinese older adults. Baseline function influences the mortality impact of cognitive changes.
UNASSIGNED: A prospective cohort study utilizing the Community Older Adults Health Survey data. Initiated in 2018, the study annually assessed all individuals aged 60+ in Dalang Town, Dongguan City. Cognitive function was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). A total of 6,042 older adults individuals were included, and multivariate Cox proportional hazard models were used to examine cognitive function\'s impact on mortality.
UNASSIGNED: Participants\' median age was 70 years, with 39% men. Over a median 3.08-year follow-up, 525 died. Mortality risk increased by 6% per MMSE score decrease (adjusted HR = 1.06, 95%CI: 1.05-1.08). Compared to those with normal cognitive function at baseline, participants with mild cognitive impairment and moderate to severe cognitive impairment had significantly higher mortality risks (adjusted HR = 1.40, 95%CI: 1.07-1.82; HR = 2.49, 95%CI: 1.91-3.24, respectively). The risk of death was 5% higher for each one-point per year decrease in cognitive function change rate (HR = 1.05, 95%CI: 1.02-1.08). Compared with participants with stable cognitive function, those with rapid cognitive decline had a 79% increased risk of death (adjusted HR = 1.79, 95% CI: 1.11-2.87), with baseline cognitive function influencing this relationship significantly (P for interaction = 0.002).
UNASSIGNED: Baseline cognitive impairment and rapid cognitive decline are associated with higher all-cause mortality risks in Chinese older adults. Baseline function influences the mortality impact of cognitive changes.
摘要：
■认知功能的关联，它的变化,全因死亡率尚未达成共识，认知功能变化与死亡率之间的相关性尚不清楚.这项研究的目的是评估60岁及以上老年人的基线认知功能和认知变化在1年内与随后的全因死亡率之间的纵向关联。
■一项利用社区老年人健康调查数据的前瞻性队列研究。这项研究始于2018年，每年评估大朗镇所有60岁以上的人，东莞市。使用中文版的简易精神状态检查（MMSE）评估认知功能。总共包括6,042名老年人，和多变量Cox比例风险模型用于检查认知功能对死亡率的影响。
■参与者的平均年龄为70岁，39%的男性超过3.08年的平均随访时间，525人死亡死亡率风险每降低一次MMSE评分增加6%(调整后HR=1.06,95CI:1.05-1.08)。与基线认知功能正常的人相比，轻度认知障碍和中度至重度认知障碍的参与者的死亡风险显著较高(校正后的HR=1.40,95CI:1.07~1.82;HR=2.49,95CI:1.91~3.24).认知功能变化率每年每下降1点，死亡风险就会增加5％（HR=1.05，95CI：1.02-1.08）。与认知功能稳定的参与者相比，认知能力快速下降的患者死亡风险增加79%(调整后的HR=1.79,95%CI:1.11-2.87),基线认知功能显著影响这种关系(交互作用的P=0.002)。
■基线认知障碍和快速认知功能下降与中国老年人全因死亡风险较高相关。基线功能影响认知变化对死亡率的影响。
■一项利用社区老年人健康调查数据的前瞻性队列研究。这项研究始于2018年，每年评估大朗镇所有60岁以上的人，东莞市。使用中文版的简易精神状态检查（MMSE）评估认知功能。总共包括6,042名老年人，和多变量Cox比例风险模型用于检查认知功能对死亡率的影响。
■参与者的平均年龄为70岁，39%的男性超过3.08年的平均随访时间，525人死亡死亡率风险每降低一次MMSE评分增加6%(调整后HR=1.06,95CI:1.05-1.08)。与基线认知功能正常的人相比，轻度认知障碍和中度至重度认知障碍的参与者的死亡风险显著较高(校正后的HR=1.40,95CI:1.07~1.82;HR=2.49,95CI:1.91~3.24).认知功能变化率每年每下降1点，死亡风险就会增加5％（HR=1.05，95CI：1.02-1.08）。与认知功能稳定的参与者相比，认知能力快速下降的患者死亡风险增加79%(调整后的HR=1.79,95%CI:1.11-2.87),基线认知功能显著影响这种关系(交互作用的P=0.002)。
■基线认知障碍和快速认知功能下降与中国老年人全因死亡风险较高相关。基线功能影响认知变化对死亡率的影响。
