PDF(Pubmed)
Abstract：
Antimicrobial resistance remains a critical global health concern, necessitating the investigation of alternative therapeutic approaches. With the diminished efficacy of conventional small molecule drugs due to the emergence of highly resilient bacterial strains, there is growing interest in the potential for alternative therapeutic modalities. As naturally occurring viruses of bacteria, bacteriophage (or phage) are being re-envisioned as a platform to engineer properties that can be tailored to target specific bacterial strains and employ diverse antibacterial mechanisms. However, limited understanding of key pharmacological properties of phage is a major challenge to translating its use from preclinical to clinical settings. Here, we review modern advancements in phage-based antimicrobial therapy and discuss the in vivo pharmacokinetics and biodistribution of phage, addressing critical challenges in their application that must be overcome for successful clinical implementation.
摘要：
抗菌素耐药性仍然是一个关键的全球健康问题，有必要研究替代治疗方法。随着常规小分子药物由于高弹性细菌菌株的出现而导致疗效下降，人们对替代治疗方式的潜力越来越感兴趣。作为自然存在的细菌病毒，噬菌体(或噬菌体)正被重新设想为设计特性的平台,所述特性可被定制以靶向特定细菌菌株并采用多种抗菌机制。然而,对噬菌体关键药理学特性的有限理解是将其从临床前应用转化为临床应用的主要挑战.这里,我们回顾了基于噬菌体的抗菌治疗的现代进展，并讨论了噬菌体的体内药代动力学和生物分布，解决其应用中的关键挑战，这些挑战必须克服才能成功实施临床。
