PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies on the liner associations between serum 25-hydroxyvitamin D [25(OH)D] levels and lipid profiles revealed ambiguous findings. The current study therefore tried to elucidate the possible non-linear associations between 25(OH)D and lipid profiles.
UNASSIGNED: This study involved 8,516 adult participants (aged 18-74 years, males N = 3,750, females N = 4,766) recruited from the Dalian health management cohort (DHMC). The risk (OR) for specific dyslipidemias was estimated across the serum 25(OH)D levels and the cut-off value for serum 25(OH)D were determined by using logistic regression, restricted cubic spline, and piecewise linear regression methods, adjusted for age, sex, season, and ultraviolet index.
UNASSIGNED: In this study, a high prevalence of 25(OH)D deficiency was observed in the participants (65.05%). The level of 25(OH)D showed the inverse U-shaped correlations with the risks (ORs) of abnormal lipid profile, with inflection points observed at 23.7 ng/ml for hypercholesterolemia, 24.3 ng/ml for hypertriglyceridemia, 18.5 ng/ml for hyper-low-density lipoprotein cholesterolemia, 23.3 ng/ml for hypo-high-density lipoprotein cholesterolemia, 23.3 ng/ml for hyper-non-high-density lipoprotein cholesterol, and 24.3 ng/ml for high remnant cholesterol. The stratified analyses showed that the risk for most dyslipidemias related to deficiency of 25(OH)D was particularly increased among females aged 50-74 (except for hypertriglyceridemia, where the highest risk was among men aged 50-74 years), during winter/spring or under low/middle ultraviolet index environments.
UNASSIGNED: Nonlinear inverse U-shaped associations were observed between 25(OH)D levels and abnormal lipid profile. The risk was particularly increased among females aged 50-74, during winter/spring period or under lower ultraviolet index environments. In vitamin D deficient subjects [25(OH)D <20 ng/ml], a positive association of serum vitamin D levels with the risk for dyslipidemia was observed, which needs a further.
UNASSIGNED: This study involved 8,516 adult participants (aged 18-74 years, males N = 3,750, females N = 4,766) recruited from the Dalian health management cohort (DHMC). The risk (OR) for specific dyslipidemias was estimated across the serum 25(OH)D levels and the cut-off value for serum 25(OH)D were determined by using logistic regression, restricted cubic spline, and piecewise linear regression methods, adjusted for age, sex, season, and ultraviolet index.
UNASSIGNED: In this study, a high prevalence of 25(OH)D deficiency was observed in the participants (65.05%). The level of 25(OH)D showed the inverse U-shaped correlations with the risks (ORs) of abnormal lipid profile, with inflection points observed at 23.7 ng/ml for hypercholesterolemia, 24.3 ng/ml for hypertriglyceridemia, 18.5 ng/ml for hyper-low-density lipoprotein cholesterolemia, 23.3 ng/ml for hypo-high-density lipoprotein cholesterolemia, 23.3 ng/ml for hyper-non-high-density lipoprotein cholesterol, and 24.3 ng/ml for high remnant cholesterol. The stratified analyses showed that the risk for most dyslipidemias related to deficiency of 25(OH)D was particularly increased among females aged 50-74 (except for hypertriglyceridemia, where the highest risk was among men aged 50-74 years), during winter/spring or under low/middle ultraviolet index environments.
UNASSIGNED: Nonlinear inverse U-shaped associations were observed between 25(OH)D levels and abnormal lipid profile. The risk was particularly increased among females aged 50-74, during winter/spring period or under lower ultraviolet index environments. In vitamin D deficient subjects [25(OH)D <20 ng/ml], a positive association of serum vitamin D levels with the risk for dyslipidemia was observed, which needs a further.
摘要：
■先前关于血清25-羟基维生素D[25(OH)D]水平与血脂谱之间的线性关联的研究显示了模糊的发现。因此，本研究试图阐明25（OH）D和脂质分布之间可能的非线性关联。
■这项研究涉及8,516名成年参与者（年龄18-74岁，从大连健康管理队列（DHMC）招募的男性N=3,750，女性N=4,766）。在血清25（OH）D水平上估计特定血脂异常的风险（OR），并使用逻辑回归确定血清25（OH）D的临界值。受限三次样条,和分段线性回归方法，根据年龄调整，性别,季节,紫外线指数。
■在这项研究中，参与者中25(OH)D缺乏的患病率较高(65.05%).25(OH)D水平与血脂异常风险(ORs)呈U型负相关,高胆固醇血症的拐点为23.7ng/ml，24.3ng/ml用于高甘油三酯血症，18.5ng/ml用于高低密度脂蛋白胆固醇血症，23.3ng/ml用于低高密度脂蛋白胆固醇血症，高非高密度脂蛋白胆固醇为23.3ng/ml，高残留胆固醇为24.3ng/ml。分层分析表明，大多数与25（OH）D缺乏相关的血脂异常的风险在50-74岁的女性中尤其增加（高甘油三酯血症除外，其中风险最高的是50-74岁的男性)，在冬季/春季或低/中紫外线指数环境下。
■在25（OH）D水平和异常脂质分布之间观察到非线性反U形关联。在冬季/春季或紫外线指数较低的环境下，年龄在50-74岁的女性中，风险尤其增加。在维生素D缺乏的受试者中[25（OH）D<20ng/ml]，观察到血清维生素D水平与血脂异常风险呈正相关,这需要进一步的。
■这项研究涉及8,516名成年参与者（年龄18-74岁，从大连健康管理队列（DHMC）招募的男性N=3,750，女性N=4,766）。在血清25（OH）D水平上估计特定血脂异常的风险（OR），并使用逻辑回归确定血清25（OH）D的临界值。受限三次样条,和分段线性回归方法，根据年龄调整，性别,季节,紫外线指数。
■在这项研究中，参与者中25(OH)D缺乏的患病率较高(65.05%).25(OH)D水平与血脂异常风险(ORs)呈U型负相关,高胆固醇血症的拐点为23.7ng/ml，24.3ng/ml用于高甘油三酯血症，18.5ng/ml用于高低密度脂蛋白胆固醇血症，23.3ng/ml用于低高密度脂蛋白胆固醇血症，高非高密度脂蛋白胆固醇为23.3ng/ml，高残留胆固醇为24.3ng/ml。分层分析表明，大多数与25（OH）D缺乏相关的血脂异常的风险在50-74岁的女性中尤其增加（高甘油三酯血症除外，其中风险最高的是50-74岁的男性)，在冬季/春季或低/中紫外线指数环境下。
■在25（OH）D水平和异常脂质分布之间观察到非线性反U形关联。在冬季/春季或紫外线指数较低的环境下，年龄在50-74岁的女性中，风险尤其增加。在维生素D缺乏的受试者中[25（OH）D<20ng/ml]，观察到血清维生素D水平与血脂异常风险呈正相关,这需要进一步的。
