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Abstract：
We wanted to evaluate if optical coherence tomography angiography OCTA findings could predict the functional outcome in extracranial carotid artery atherosclerotic disease (ECAD) associated stroke. This exploratory study was performed on adults with acute ischaemic stroke due to ECAD at 3-6 weeks following stroke onset with risk factor matched controls without carotid artery stenosis. Twenty-three stroke patients (cases) and 23 controls were enrolled. There was significant difference between cases and controls in deep vessel density at the macula (p = .0007) and in radial peripapillary capillary perfusion density (RPCPD) at the optic nerve head (ONH) (p = .0007). Statistically significant difference was noted in the total superficial vessel density (SVD) at the macula (SVD within 1 standard deviation [SD] versus SVD beyond 1 SD of control data) in the ipsilateral eye and functional outcome at 3 months (poor versus very good outcome, modified Rankin scale [mRS] 0-1 versus mRS 2-6, respectively; p = .0361). There was statistically insignificant correlation between the RPCPD at the ONH and the National Institutes of Health Stroke Scale score at admission, mRS at discharge, and mRS at 3 months following stroke onset (r = .33, r = .35, r = .39; p = .11, p = .09, p = .06, respectively). The findings of this exploratory study suggested that OCTA findings may predict 3 month outcomes in cases of ECAD-related stroke and could be useful in decision making in future intervention studies as to whether intervene or not in patients having critical or non-critical ECAD for preventing stroke.
摘要：
我们想评估光学相干断层扫描血管造影OCTA结果是否可以预测颅外颈动脉粥样硬化疾病（ECAD）相关卒中的功能结局。这项探索性研究是针对中风发作后3-6周因ECAD引起的急性缺血性中风的成年人进行的，其危险因素与对照组相匹配，但没有颈动脉狭窄。纳入23例中风患者（病例）和23例对照。病例与对照组之间的黄斑深血管密度（p=.0007）和视神经头（ONH）的放射状乳头周围毛细血管灌注密度（RPCPD）（p=.0007）存在显着差异。同侧眼黄斑总浅表血管密度（SVD）（SVD在1个标准差[SD]内与对照数据的SVD超过1个标准差）和3个月时的功能结局（差与非常好的结局，改良的兰金量表[mRS]0-1和mRS2-6分别为；p=.0361)。ONH的RPCPD与入院时的美国国立卫生研究院卒中量表评分之间的相关性无统计学意义，放电时的mRS，和mRS在卒中发作后3个月(分别为r=.33,r=.35,r=.39;p=.11,p=.09,p=.06)。这项探索性研究的结果表明，OCTA的发现可以预测ECAD相关卒中的3个月结局，并可用于未来干预研究的决策，即是否干预危重或非危重ECAD患者以预防卒中。
