PDF(Pubmed)
Abstract：
UNASSIGNED: The study aimed to investigate the diagnostic values of different musculoskeletal ultrasound (MSUS) signs, serum uric acid (SUA), and their combined detection for gouty arthritis (GA).
UNASSIGNED: In this retrospective study, 70 patients (62 males, 8 females; mean age: 46.1±14.1 years; range, 25 to 86 years) diagnosed with GA (the GA group) between August 2022 and March 2023 and 70 patients (54 females, 16 males; mean age: 49.0±14.1 years; range, 21 to 75 years) diagnosed with rheumatoid arthritis and osteoarthritis during the same period (the non-GA group) were included. The positive rate of MSUS signs and SUA in both groups was recorded to compare the differences. The correlations of MSUS signs and SUA with GA were analyzed using Spearman\'s rank correlation analysis. The diagnostic values of different MSUS signs, SUA, and their combined detection for GA were analyzed using a receiver operating characteristic, the area under the curve (AUC), sensitivity, specificity, and the Youden index.
UNASSIGNED: The positive rate of the double contour (DC) sign (chi-squared [χ2 ]=102.935, p<0.001), hyperechoic spots (χ2=56.395, p<0.001), bone erosions (χ2 =10.080, p<0.001), and SUA (χ2 =41.117, p <0.001) were higher in the GA group than in the non-GA group. The positive rate of the DC sign (rs=0.829, p=0.001), hyperechoic spots (rs=0.631, p<0.001), bone erosion (rs=0.268, p=0.001), and SUA (rs=0.542, p<0.001) were positively correlated with GA. Among the single-indicator measures, the DC sign exhibited the highest diagnostic value (AUC=0.907, sensitivity=81.4%, specificity=100%, p<0.001). Among the combined-indicator measures, the DC sign combined with SUA exhibited the highest diagnostic value (AUC=0.929, sensitivity=91.4%, specificity=94.3%, p<0.001), higher than DC sign detection alone.
UNASSIGNED: The DC sign combined with SUA yielded a high diagnostic value and can thus provide a reliable basis for effectively and efficiently diagnosing GA.
UNASSIGNED: In this retrospective study, 70 patients (62 males, 8 females; mean age: 46.1±14.1 years; range, 25 to 86 years) diagnosed with GA (the GA group) between August 2022 and March 2023 and 70 patients (54 females, 16 males; mean age: 49.0±14.1 years; range, 21 to 75 years) diagnosed with rheumatoid arthritis and osteoarthritis during the same period (the non-GA group) were included. The positive rate of MSUS signs and SUA in both groups was recorded to compare the differences. The correlations of MSUS signs and SUA with GA were analyzed using Spearman\'s rank correlation analysis. The diagnostic values of different MSUS signs, SUA, and their combined detection for GA were analyzed using a receiver operating characteristic, the area under the curve (AUC), sensitivity, specificity, and the Youden index.
UNASSIGNED: The positive rate of the double contour (DC) sign (chi-squared [χ2 ]=102.935, p<0.001), hyperechoic spots (χ2=56.395, p<0.001), bone erosions (χ2 =10.080, p<0.001), and SUA (χ2 =41.117, p <0.001) were higher in the GA group than in the non-GA group. The positive rate of the DC sign (rs=0.829, p=0.001), hyperechoic spots (rs=0.631, p<0.001), bone erosion (rs=0.268, p=0.001), and SUA (rs=0.542, p<0.001) were positively correlated with GA. Among the single-indicator measures, the DC sign exhibited the highest diagnostic value (AUC=0.907, sensitivity=81.4%, specificity=100%, p<0.001). Among the combined-indicator measures, the DC sign combined with SUA exhibited the highest diagnostic value (AUC=0.929, sensitivity=91.4%, specificity=94.3%, p<0.001), higher than DC sign detection alone.
UNASSIGNED: The DC sign combined with SUA yielded a high diagnostic value and can thus provide a reliable basis for effectively and efficiently diagnosing GA.
摘要：
■该研究旨在探讨不同肌肉骨骼超声（MSUS）体征的诊断价值，血清尿酸（SUA），以及它们对痛风性关节炎(GA)的联合检测。
■在这项回顾性研究中，70名患者（62名男性，8名女性；平均年龄：46.1±14.1岁；范围，25至86岁）在2022年8月至2023年3月之间诊断为GA（GA组），有70名患者（54名女性，16名男性；平均年龄：49.0±14.1岁；范围，包括同期（非GA组）诊断为类风湿关节炎和骨关节炎的21至75岁）。记录两组的MSUS体征和SUA阳性率，以比较差异。采用Spearman秩相关分析MSUS征象和SUA与GA的相关性。不同MSUS征象的诊断价值,SUA,并使用接收器工作特性分析了它们对GA的组合检测，曲线下面积（AUC），灵敏度,特异性，和Youden指数。
■双轮廓（DC）符号的阳性率（卡方[χ2]=102.935，p<0.001），高回声斑点（χ2=56.395，p<0.001），骨侵蚀（χ2=10.080，p<0.001），GA组SUA(χ2=41.117,p<0.001)高于非GA组。DC符号的阳性率（rs=0.829，p=0.001），高回声斑点（rs=0.631，p<0.001），骨侵蚀（rs=0.268，p=0.001），SUA与GA呈正相关(rs=0.542,p<0.001)。在单一指标措施中，DC征象表现出最高的诊断价值(AUC=0.907,灵敏度=81.4%,特异性=100%，p<0.001)。在综合指标措施中，DC征象联合SUA表现出最高的诊断价值(AUC=0.929,灵敏度=91.4%,特异性=94.3%，p<0.001)，高于单独的DC信号检测。
■与SUA结合的DC符号产生了很高的诊断价值，因此可以为有效和高效地诊断GA提供可靠的依据。
■在这项回顾性研究中，70名患者（62名男性，8名女性；平均年龄：46.1±14.1岁；范围，25至86岁）在2022年8月至2023年3月之间诊断为GA（GA组），有70名患者（54名女性，16名男性；平均年龄：49.0±14.1岁；范围，包括同期（非GA组）诊断为类风湿关节炎和骨关节炎的21至75岁）。记录两组的MSUS体征和SUA阳性率，以比较差异。采用Spearman秩相关分析MSUS征象和SUA与GA的相关性。不同MSUS征象的诊断价值,SUA,并使用接收器工作特性分析了它们对GA的组合检测，曲线下面积（AUC），灵敏度,特异性，和Youden指数。
■双轮廓（DC）符号的阳性率（卡方[χ2]=102.935，p<0.001），高回声斑点（χ2=56.395，p<0.001），骨侵蚀（χ2=10.080，p<0.001），GA组SUA(χ2=41.117,p<0.001)高于非GA组。DC符号的阳性率（rs=0.829，p=0.001），高回声斑点（rs=0.631，p<0.001），骨侵蚀（rs=0.268，p=0.001），SUA与GA呈正相关(rs=0.542,p<0.001)。在单一指标措施中，DC征象表现出最高的诊断价值(AUC=0.907,灵敏度=81.4%,特异性=100%，p<0.001)。在综合指标措施中，DC征象联合SUA表现出最高的诊断价值(AUC=0.929,灵敏度=91.4%,特异性=94.3%，p<0.001)，高于单独的DC信号检测。
■与SUA结合的DC符号产生了很高的诊断价值，因此可以为有效和高效地诊断GA提供可靠的依据。
