PDF(Pubmed)
Abstract：
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). H2S is crucial in various physiological processes associated with female mammalian reproduction. These include estrus cycle, oocyte maturation, oocyte aging, ovulation, embryo transport and early embryo development, the development of the placenta and fetal membranes, pregnancy, and the initiation of labor. Despite the confirmed presence of H2S-producing enzymes in all female reproductive tissues, as described in this review, the exact mechanisms of H2S action in these tissues remain in most cases unclear. Therefore, this review aims to summarize the knowledge about the presence and effects of H2S in these tissues and outline possible signaling pathways that mediate these effects. Understanding these pathways may lead to the development of new therapeutic strategies in the field of women\'s health and perinatal medicine.
摘要：
硫化氢（H2S）是由三种酶在体内产生的气态信号分子：cystathionine-β-合酶（CBS），胱硫醚-γ-裂解酶（CSE）和3-巯基丙酮酸硫转移酶（3-MST）。H2S在与雌性哺乳动物繁殖相关的各种生理过程中至关重要。这些包括发情周期，卵母细胞成熟,卵母细胞老化,排卵,胚胎运输和早期胚胎发育，胎盘和胎膜的发育，怀孕,和劳动的开始。尽管确认所有雌性生殖组织中都存在产生H2S的酶，如这篇评论所述，H2S在这些组织中作用的确切机制在大多数情况下仍不清楚。因此,这篇综述旨在总结有关H2S在这些组织中的存在和作用的知识，并概述介导这些作用的可能信号通路。了解这些途径可能会导致妇女健康和围产期医学领域新的治疗策略的发展。
