PDF(Pubmed)
Abstract：
UNASSIGNED: We conducted an overview to assess immune adverse effects associated with the COVID-19 vaccine, guiding safer choices and providing evidence-based information to clinicians.
UNASSIGNED: Forty-three studies on adverse effects of vaccines were reviewed from PubMed, Embase, and Web of Science. Single-arm meta-analyses estimated summary effects, incidence, presentation, etc. An overview using single-arm meta-analysis and reported the findings following the guidelines outlined in the \'Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) specifically focusing on myocarditis and thrombosis. After screening 2,591 articles, 42 studies met the inclusion criteria. Methodological quality was evaluated using AMSTAR 2. Disagreements were resolved via consensus. Data analysis utilized a random-effects model in R software to estimate incidence rates of selected adverse events.
UNASSIGNED: After removing 1,198 duplicates and screening out irrelevant articles from a total of 2,591, we included 42 studies. Adverse reactions to vaccinations include myocarditis, thrombosis, skin reactions, GBS, etc. thrombosis and myocarditis are the most dangerous diseases associated with vaccination. Myocarditis occurred in 6% of Vector vaccine recipients, compared to 61% of mRNA vaccine recipients. Thrombosis was more common after Vector vaccination (91%) than after mRNA vaccination (9%). Furthermore, eight studies conducted anti-PF4 antibody tests and yielded a positivity rate of 67%. Meta-analysis showed that among all patients with Vaccine-induced Thrombotic Thrombocytopenia, cerebral venous sinus thrombosis occurred in 66%, and intracranial hemorrhage occurred in 43%. The rates of deep vein thrombosis and pulmonary thromboembolism in vaccinated patients were 13% and 23%, respectively, with a pooled case fatality rate of 30%.
UNASSIGNED: The results of this overview indicate the majority of adverse reactions are self-limiting and require minimal intervention, while rare occurrences such as myocarditis and thrombosis pose a potentially fatal threat.
UNASSIGNED: Forty-three studies on adverse effects of vaccines were reviewed from PubMed, Embase, and Web of Science. Single-arm meta-analyses estimated summary effects, incidence, presentation, etc. An overview using single-arm meta-analysis and reported the findings following the guidelines outlined in the \'Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) specifically focusing on myocarditis and thrombosis. After screening 2,591 articles, 42 studies met the inclusion criteria. Methodological quality was evaluated using AMSTAR 2. Disagreements were resolved via consensus. Data analysis utilized a random-effects model in R software to estimate incidence rates of selected adverse events.
UNASSIGNED: After removing 1,198 duplicates and screening out irrelevant articles from a total of 2,591, we included 42 studies. Adverse reactions to vaccinations include myocarditis, thrombosis, skin reactions, GBS, etc. thrombosis and myocarditis are the most dangerous diseases associated with vaccination. Myocarditis occurred in 6% of Vector vaccine recipients, compared to 61% of mRNA vaccine recipients. Thrombosis was more common after Vector vaccination (91%) than after mRNA vaccination (9%). Furthermore, eight studies conducted anti-PF4 antibody tests and yielded a positivity rate of 67%. Meta-analysis showed that among all patients with Vaccine-induced Thrombotic Thrombocytopenia, cerebral venous sinus thrombosis occurred in 66%, and intracranial hemorrhage occurred in 43%. The rates of deep vein thrombosis and pulmonary thromboembolism in vaccinated patients were 13% and 23%, respectively, with a pooled case fatality rate of 30%.
UNASSIGNED: The results of this overview indicate the majority of adverse reactions are self-limiting and require minimal intervention, while rare occurrences such as myocarditis and thrombosis pose a potentially fatal threat.
摘要：
■我们进行了一项概述，以评估与COVID-19疫苗相关的免疫不良反应，指导更安全的选择，并为临床医生提供循证信息。
■回顾了PubMed关于疫苗不良反应的43项研究，Embase,和WebofScience。单臂荟萃分析估计的汇总效果，发病率,介绍,等。使用单臂荟萃分析进行概述，并根据“系统评价和荟萃分析（PRISMA）的首选报告项目”中概述的指南报告了发现，该报告专门针对心肌炎和血栓形成。在筛选了2591篇文章后，42项研究符合纳入标准。使用AMSTAR2评估方法学质量。分歧通过协商一致解决。数据分析利用R软件中的随机效应模型来估计所选不良事件的发生率。
在删除1,198个重复项并从总共2,591个中筛选出无关文章后，我们纳入了42个研究。接种疫苗的不良反应包括心肌炎，血栓形成,皮肤反应,GBS,等。血栓形成和心肌炎是与疫苗接种相关的最危险的疾病。6％的Vector疫苗接种者发生心肌炎，与61%的mRNA疫苗接种者相比。Vector疫苗接种后（91%）血栓形成比mRNA疫苗接种后（9%）更常见。此外，8项研究进行了抗PF4抗体检测,阳性率为67%.Meta分析显示,在所有疫苗诱导的血栓性血小板减少症患者中,66%的患者发生脑静脉窦血栓,43％发生颅内出血。接种疫苗的患者深静脉血栓形成和肺血栓栓塞的发生率分别为13%和23%,分别,合并病例死亡率为30%。
■本概述的结果表明，大多数不良反应是自限性的，需要最少的干预，而心肌炎和血栓形成等罕见事件构成潜在的致命威胁。
■回顾了PubMed关于疫苗不良反应的43项研究，Embase,和WebofScience。单臂荟萃分析估计的汇总效果，发病率,介绍,等。使用单臂荟萃分析进行概述，并根据“系统评价和荟萃分析（PRISMA）的首选报告项目”中概述的指南报告了发现，该报告专门针对心肌炎和血栓形成。在筛选了2591篇文章后，42项研究符合纳入标准。使用AMSTAR2评估方法学质量。分歧通过协商一致解决。数据分析利用R软件中的随机效应模型来估计所选不良事件的发生率。
在删除1,198个重复项并从总共2,591个中筛选出无关文章后，我们纳入了42个研究。接种疫苗的不良反应包括心肌炎，血栓形成,皮肤反应,GBS,等。血栓形成和心肌炎是与疫苗接种相关的最危险的疾病。6％的Vector疫苗接种者发生心肌炎，与61%的mRNA疫苗接种者相比。Vector疫苗接种后（91%）血栓形成比mRNA疫苗接种后（9%）更常见。此外，8项研究进行了抗PF4抗体检测,阳性率为67%.Meta分析显示,在所有疫苗诱导的血栓性血小板减少症患者中,66%的患者发生脑静脉窦血栓,43％发生颅内出血。接种疫苗的患者深静脉血栓形成和肺血栓栓塞的发生率分别为13%和23%,分别,合并病例死亡率为30%。
■本概述的结果表明，大多数不良反应是自限性的，需要最少的干预，而心肌炎和血栓形成等罕见事件构成潜在的致命威胁。
