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Abstract：
Background Knee osteoarthritis (KOA), a degenerative joint disease, is a common cause of chronic knee pain and disability in adults. Conservative management options are the first-line approach, but intra-articular injections, such as platelet-rich plasma (PRP) and hyaluronic acid (HA), are considered for advanced cases. This study aims to compare the efficacy of PRP versus HA injections in patients with advanced KOA. Methods A retrospective study was conducted on 145 patients with advanced KOA. Seventy patients received PRP injections, while 75 patients received HA injections. The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and International Knee Documentation Committee (IKDC) score were employed to evaluate the treatment\'s efficacy. Adverse events associated with these injections were also recorded. Results Both PRP and HA injections significantly reduced pain and improved joint function in patients with advanced KOA. PRP injections were slightly more effective than HA injections in reducing pain scores. Both treatments showed similar improvements in functional outcomes. Adverse events were minimal and self-limiting for both treatments. Conclusions Both PRP and HA injections effectively ameliorate advanced KOA by reducing pain and improving function. PRP injections showed a slightly greater improvement in pain scores and functional outcomes. The choice between PRP and HA injections may depend on factors like cost, availability, and patient preference. Further research is needed to validate these findings and understand treatment suitability for different patient populations.
摘要：
背景膝骨关节炎（KOA），退行性关节病,是成人慢性膝关节疼痛和残疾的常见原因。保守的管理选择是第一线的方法，但是关节内注射,如富血小板血浆（PRP）和透明质酸（HA），被认为是先进的情况下。这项研究旨在比较PRP与HA注射在晚期KOA患者中的疗效。方法对145例晚期KOA患者进行回顾性研究。70名患者接受了PRP注射，75名患者接受HA注射。视觉模拟刻度(VAS)，西安大略省和麦克马斯特大学骨关节炎指数（WOMAC）评分，采用国际膝关节文献委员会（IKDC）评分评估治疗疗效。还记录了与这些注射相关的不良事件。结果PRP和HA注射均能明显减轻晚期KOA患者的疼痛，改善关节功能。PRP注射在降低疼痛评分方面比HA注射稍微更有效。两种治疗在功能结果上显示出相似的改善。两种治疗的不良事件都是最小的和自我限制的。结论PRP和HA注射均可通过减轻疼痛和改善功能来有效改善晚期KOA。PRP注射显示疼痛评分和功能结果的改善稍大。PRP和HA注射之间的选择可能取决于成本等因素，可用性,患者偏好。需要进一步的研究来验证这些发现并了解不同患者人群的治疗适用性。
