PDF(Pubmed)
Abstract：
UNASSIGNED: To establish a modified nomogram model for pancreatic neuroendocrine carcinoma (pNEC) patients with liver metastasis via single-center clinical data, and to provide guidelines for improving the diagnosis and treatment of patients.
UNASSIGNED: A retrospective analysis of clinical data from pNEC patients with liver metastasis at Peking Union Medical College Hospital (January 2000 to November 2023) was conducted. Univariate and multivariate Cox regression analyses were employed to identify prognostic factors for overall survival (OS). Kaplan-Meier curves were generated, and a modified nomogram predictive model was developed to illustrate the prognosis of pNEC patients with liver metastasis. Calibration plots and C-index were used to validate the model\'s feasibility, accuracy, and reliability.
UNASSIGNED: Forty-five participants with the rare cancer type pNEC and liver metastasis were included in the study. Kaplan-Meier curves revealed that primary tumor resection (PTR), chemotherapy or targeted therapy, and tumor size equal to or less than 5cm significantly improved OS compared to those without PTR, chemotherapy or targeted therapy, and tumor size larger than 5cm. Multivariate Cox regression analysis identified PTR, a combination of chemotherapy and targeted therapy, and tumor size as independent prognostic factors for OS. The predictive nomogram model exhibited acceptable performance with a C-index of 0.744 (0.639-0.805) through bootstrapping.
UNASSIGNED: Combining chemotherapy with targeted therapy enhances the survival of pNEC patients with liver metastasis. The modified nomogram model and predictive score table offer valuable references and insights for both clinicians and patients.
UNASSIGNED: A retrospective analysis of clinical data from pNEC patients with liver metastasis at Peking Union Medical College Hospital (January 2000 to November 2023) was conducted. Univariate and multivariate Cox regression analyses were employed to identify prognostic factors for overall survival (OS). Kaplan-Meier curves were generated, and a modified nomogram predictive model was developed to illustrate the prognosis of pNEC patients with liver metastasis. Calibration plots and C-index were used to validate the model\'s feasibility, accuracy, and reliability.
UNASSIGNED: Forty-five participants with the rare cancer type pNEC and liver metastasis were included in the study. Kaplan-Meier curves revealed that primary tumor resection (PTR), chemotherapy or targeted therapy, and tumor size equal to or less than 5cm significantly improved OS compared to those without PTR, chemotherapy or targeted therapy, and tumor size larger than 5cm. Multivariate Cox regression analysis identified PTR, a combination of chemotherapy and targeted therapy, and tumor size as independent prognostic factors for OS. The predictive nomogram model exhibited acceptable performance with a C-index of 0.744 (0.639-0.805) through bootstrapping.
UNASSIGNED: Combining chemotherapy with targeted therapy enhances the survival of pNEC patients with liver metastasis. The modified nomogram model and predictive score table offer valuable references and insights for both clinicians and patients.
摘要：
■通过单中心临床数据建立胰腺神经内分泌癌（pNEC）肝转移患者的改良列线图模型，并为改善患者的诊断和治疗提供指导。
■对北京协和医院（2000年1月至2023年11月）的pNEC肝转移患者的临床资料进行了回顾性分析。采用单变量和多变量Cox回归分析来确定总生存期（OS）的预后因素。生成Kaplan-Meier曲线,并建立了改良的列线图预测模型来说明pNEC肝转移患者的预后。使用校准图和C指数来验证模型的可行性，准确度,和可靠性。
■45名患有罕见癌症类型pNEC和肝转移的参与者被纳入研究。Kaplan-Meier曲线显示原发性肿瘤切除术(PTR)，化疗或靶向治疗，与没有PTR的肿瘤相比，肿瘤大小等于或小于5cm的肿瘤显著提高了OS，化疗或靶向治疗，肿瘤大小大于5cm。多变量Cox回归分析确定PTR，化疗和靶向治疗相结合，肿瘤大小是OS的独立预后因素。预测列线图模型通过自举表现出可接受的性能，C指数为0.744（0.639-0.805）。
■化疗联合靶向治疗可提高pNEC肝转移患者的生存率。改进的列线图模型和预测评分表为临床医生和患者提供了有价值的参考和见解。
■对北京协和医院（2000年1月至2023年11月）的pNEC肝转移患者的临床资料进行了回顾性分析。采用单变量和多变量Cox回归分析来确定总生存期（OS）的预后因素。生成Kaplan-Meier曲线,并建立了改良的列线图预测模型来说明pNEC肝转移患者的预后。使用校准图和C指数来验证模型的可行性，准确度,和可靠性。
■45名患有罕见癌症类型pNEC和肝转移的参与者被纳入研究。Kaplan-Meier曲线显示原发性肿瘤切除术(PTR)，化疗或靶向治疗，与没有PTR的肿瘤相比，肿瘤大小等于或小于5cm的肿瘤显著提高了OS，化疗或靶向治疗，肿瘤大小大于5cm。多变量Cox回归分析确定PTR，化疗和靶向治疗相结合，肿瘤大小是OS的独立预后因素。预测列线图模型通过自举表现出可接受的性能，C指数为0.744（0.639-0.805）。
■化疗联合靶向治疗可提高pNEC肝转移患者的生存率。改进的列线图模型和预测评分表为临床医生和患者提供了有价值的参考和见解。
