PDF(Pubmed)
Abstract：
UNASSIGNED: Serum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there is a causal association between them remains uncertain.
UNASSIGNED: Conduct a two-sample Mendelian randomization (MR) analysis to investigate the causal effect between serum 25-hydroxyvitamin D level and ED risk.
UNASSIGNED: Genome-wide association study (GWAS) data of serum 25-hydroxyvitamin D levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people of European ancestry were regarded as exposure for the MR analysis. Additional GWAS data involving 9,310,196 SNPs of 6,175 European ED cases and 217,630 controls were used as outcome data. The MR-Egger, inverse variance weighted (IVW) method, weighted median, simple mode, and weighted mode were employed to evaluate causal effects, among which IVW was the primary MR analysis method. The stability of the MR analysis results was confirmed by a heterogeneity test, a horizontal pleiotropy test, and the leave-one-out method.
UNASSIGNED: There were 103 SNPs utilized as instrumental variables (p < 5 × 10-8). The results of MR analysis showed no causal effects of serum 25(OH) D concentration on ED risks (IVW; OR = 0.9516, 95% CI = 0.7994 to 1.1328, p = 0.5772). There was no heterogeneity and pleiotropy in the statistical models.
UNASSIGNED: The present MR study did not support a causal association for genetically predicted serum 25-hydroxyvitamin D concentration in the risk of ED in individuals of European descent.
UNASSIGNED: Conduct a two-sample Mendelian randomization (MR) analysis to investigate the causal effect between serum 25-hydroxyvitamin D level and ED risk.
UNASSIGNED: Genome-wide association study (GWAS) data of serum 25-hydroxyvitamin D levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people of European ancestry were regarded as exposure for the MR analysis. Additional GWAS data involving 9,310,196 SNPs of 6,175 European ED cases and 217,630 controls were used as outcome data. The MR-Egger, inverse variance weighted (IVW) method, weighted median, simple mode, and weighted mode were employed to evaluate causal effects, among which IVW was the primary MR analysis method. The stability of the MR analysis results was confirmed by a heterogeneity test, a horizontal pleiotropy test, and the leave-one-out method.
UNASSIGNED: There were 103 SNPs utilized as instrumental variables (p < 5 × 10-8). The results of MR analysis showed no causal effects of serum 25(OH) D concentration on ED risks (IVW; OR = 0.9516, 95% CI = 0.7994 to 1.1328, p = 0.5772). There was no heterogeneity and pleiotropy in the statistical models.
UNASSIGNED: The present MR study did not support a causal association for genetically predicted serum 25-hydroxyvitamin D concentration in the risk of ED in individuals of European descent.
摘要：
■在观察性研究中，血清25-羟基维生素D水平与勃起功能障碍（ED）相关。然而,它们之间是否存在因果关系仍然不确定。
■进行两个样本的孟德尔随机化（MR）分析，以调查血清25-羟基维生素D水平与ED风险之间的因果关系。
■来自496,949名欧洲血统的人的血清25-羟基维生素D水平的全基因组关联研究（GWAS）数据，包括6,896,093个单核苷酸多态性（SNP），被视为MR分析的暴露。其他GWAS数据涉及6,175例欧洲ED病例和217,630例对照中的9,310,196个SNP被用作结果数据。MR-Egger,逆方差加权(IVW)方法，加权中位数，简单模式，并采用加权模式来评估因果效应，其中IVW是主要的MR分析方法。通过异质性测试证实了MR分析结果的稳定性，水平多效性测试，和留一法。
■有103个SNP用作工具变量（p<5×10-8）。MR分析结果表明，血清25（OH）D浓度对ED风险没有因果关系（IVW;OR=0.9516，95％CI=0.7994至1.1328，p=0.5772）。统计模型中没有异质性和多效性。
■目前的MR研究不支持基因预测的血清25-羟基维生素D浓度与欧洲血统个体ED风险的因果关系。
■进行两个样本的孟德尔随机化（MR）分析，以调查血清25-羟基维生素D水平与ED风险之间的因果关系。
■来自496,949名欧洲血统的人的血清25-羟基维生素D水平的全基因组关联研究（GWAS）数据，包括6,896,093个单核苷酸多态性（SNP），被视为MR分析的暴露。其他GWAS数据涉及6,175例欧洲ED病例和217,630例对照中的9,310,196个SNP被用作结果数据。MR-Egger,逆方差加权(IVW)方法，加权中位数，简单模式，并采用加权模式来评估因果效应，其中IVW是主要的MR分析方法。通过异质性测试证实了MR分析结果的稳定性，水平多效性测试，和留一法。
■有103个SNP用作工具变量（p<5×10-8）。MR分析结果表明，血清25（OH）D浓度对ED风险没有因果关系（IVW;OR=0.9516，95％CI=0.7994至1.1328，p=0.5772）。统计模型中没有异质性和多效性。
■目前的MR研究不支持基因预测的血清25-羟基维生素D浓度与欧洲血统个体ED风险的因果关系。
