PDF(Pubmed)
Abstract：
UNASSIGNED: Traumatic brain injury (TBI) is one of the leading causes of all injury-related deaths and disabilities in the world, especially in low to middle-income countries (LMICs) which also suffer from lower levels of funding for all levels of the health care system for patients suffering from TBI. These patients do not generally get comprehensive diagnostic workup, monitoring, or treatment, and return to work too quickly, often with undiagnosed post-traumatic deficits which in turn can lead to subsequent incidents of physical harm.
UNASSIGNED: Here, we share methods and results from our research project to establish innovative, simple, and scientifically based practices that dramatically leverage technology and validated testing strategies to identify post-TBI deficits quickly and accurately, to circumvent economic realities on the ground in LMICs. We utilized paper tests such as the Montreal cognitive assessment (MoCA), line-bisection, and Bell\'s test. Furthermore, we combined modifications of neuroscience computer tasks to aid in assessing peripheral vision, memory, and analytical accuracies. Data from seventy-one subjects (51 patients and 20 controls, 15 females and 56 males) from 4 hospitals in Ethiopia are presented. The traumatic brain injury group consists of 17 mild, 28 moderate, and 8 severe patients (based on the initial Glasgow Comma Score). Controls are age and education-matched subjects (no known history of TBI, brain lesions, or spatial neglect symptoms).
UNASSIGNED: We found these neurophysiological methods can: 1) be implemented in LMICs and 2) test impairments caused by TBI, which generally affect brain processing speed, memory, and both executive and cognitive controls.
UNASSIGNED: The main findings indicate that these examinations can identify several deficits, especially the MoCA test. These tests show great promise to assist in the evaluation of TBI patients and support the establishment of dedicated rehabilitation centers. Our next steps will be expansion of the cohort size and application of the tests to other settings.
UNASSIGNED: Here, we share methods and results from our research project to establish innovative, simple, and scientifically based practices that dramatically leverage technology and validated testing strategies to identify post-TBI deficits quickly and accurately, to circumvent economic realities on the ground in LMICs. We utilized paper tests such as the Montreal cognitive assessment (MoCA), line-bisection, and Bell\'s test. Furthermore, we combined modifications of neuroscience computer tasks to aid in assessing peripheral vision, memory, and analytical accuracies. Data from seventy-one subjects (51 patients and 20 controls, 15 females and 56 males) from 4 hospitals in Ethiopia are presented. The traumatic brain injury group consists of 17 mild, 28 moderate, and 8 severe patients (based on the initial Glasgow Comma Score). Controls are age and education-matched subjects (no known history of TBI, brain lesions, or spatial neglect symptoms).
UNASSIGNED: We found these neurophysiological methods can: 1) be implemented in LMICs and 2) test impairments caused by TBI, which generally affect brain processing speed, memory, and both executive and cognitive controls.
UNASSIGNED: The main findings indicate that these examinations can identify several deficits, especially the MoCA test. These tests show great promise to assist in the evaluation of TBI patients and support the establishment of dedicated rehabilitation centers. Our next steps will be expansion of the cohort size and application of the tests to other settings.
摘要：
■创伤性脑损伤（TBI）是世界上所有与伤害相关的死亡和残疾的主要原因之一，特别是在中低收入国家（LMICs），这些国家对患有TBI的患者的各级医疗保健系统的供资水平也较低。这些患者通常不会得到全面的诊断检查，监测,或治疗，太快地返回工作，通常患有未诊断的创伤后缺陷，这反过来又可能导致随后的身体伤害事件。
■这里，我们分享我们研究项目的方法和成果，以建立创新，简单,和基于科学的实践，这些实践极大地利用技术和经过验证的测试策略来快速准确地识别TBI后的缺陷，规避LMICs当地的经济现实。我们使用了诸如蒙特利尔认知评估（MoCA）之类的纸质测试，线平分，和贝尔的测试。此外，我们结合了神经科学计算机任务的修改来帮助评估周边视觉，记忆,和分析准确性。来自71名受试者的数据(51名患者和20名对照，介绍了埃塞俄比亚4家医院的15名女性和56名男性）。创伤性脑损伤组包括17名轻度，28中度，和8名严重患者（基于初始格拉斯哥逗号评分）。对照是年龄和教育匹配的受试者(没有已知的TBI病史，脑部病变,或空间忽视症状)。
■我们发现这些神经生理学方法可以：1）在LMIC中实施，2）由TBI引起的测试损伤，通常会影响大脑处理速度，记忆,以及执行和认知控制。
■主要发现表明，这些检查可以发现几个缺陷，尤其是MoCA测试。这些测试显示出极大的希望，可以帮助评估TBI患者并支持建立专门的康复中心。我们的下一步将是扩大队列规模和将测试应用于其他设置。
■这里，我们分享我们研究项目的方法和成果，以建立创新，简单,和基于科学的实践，这些实践极大地利用技术和经过验证的测试策略来快速准确地识别TBI后的缺陷，规避LMICs当地的经济现实。我们使用了诸如蒙特利尔认知评估（MoCA）之类的纸质测试，线平分，和贝尔的测试。此外，我们结合了神经科学计算机任务的修改来帮助评估周边视觉，记忆,和分析准确性。来自71名受试者的数据(51名患者和20名对照，介绍了埃塞俄比亚4家医院的15名女性和56名男性）。创伤性脑损伤组包括17名轻度，28中度，和8名严重患者（基于初始格拉斯哥逗号评分）。对照是年龄和教育匹配的受试者(没有已知的TBI病史，脑部病变,或空间忽视症状)。
■我们发现这些神经生理学方法可以：1）在LMIC中实施，2）由TBI引起的测试损伤，通常会影响大脑处理速度，记忆,以及执行和认知控制。
■主要发现表明，这些检查可以发现几个缺陷，尤其是MoCA测试。这些测试显示出极大的希望，可以帮助评估TBI患者并支持建立专门的康复中心。我们的下一步将是扩大队列规模和将测试应用于其他设置。
