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Abstract：
UNASSIGNED: This study aims to investigate the factors affecting development of acute kidney injury (AKI) in patients with severe hypothyroidism.
UNASSIGNED: This retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Factors affecting the development of AKI were examined by logistic regression analysis.
UNASSIGNED: A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3-68.5) was significantly higher than the control group (49 years, IQR 32.3-60; p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955-598.031; p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491-118.089; p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602-82.848; p = 0.015) were predictors for the development of AKI in patients with severe hypothyroidism.
UNASSIGNED: We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if patients who are diagnosed at age > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.
UNASSIGNED: This retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Factors affecting the development of AKI were examined by logistic regression analysis.
UNASSIGNED: A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3-68.5) was significantly higher than the control group (49 years, IQR 32.3-60; p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955-598.031; p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491-118.089; p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602-82.848; p = 0.015) were predictors for the development of AKI in patients with severe hypothyroidism.
UNASSIGNED: We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if patients who are diagnosed at age > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.
摘要：
■本研究旨在探讨影响严重甲状腺功能减退症患者急性肾损伤（AKI）发展的因素。
■这项回顾性观察性研究涉及原发性甲状腺功能减退症和促甲状腺激素（TSH）水平超过50mIU/L的患者，2015年1月至2021年4月。Logistic回归分析影响AKI发生发展的因素。
■总共100名患者，20（11名男性（M），9名女性（F））在AKI（病例）组中和80（23M，57F）对照组患者，包括在我们的研究中。病例组的中位年龄(56岁，四分位距（IQR）44.3-68.5）显着高于对照组（49岁，IQR32.3-60；p=0.027），病例组男女比例明显较高(p=0.001)。多因素logistic回归分析显示，60岁后诊断为甲状腺功能减退（比值比（OR）59.674，95％置信区间（CI）5.955-598.031;p=0.001），游离三碘甲状腺原氨酸(FT3)<1.3pg/mL(OR17.151,95%CI2.491-118.089;p=0.004)和肌酸激酶(CK)>1000U/L(OR1.522,95%CI1.602-82.848;p=0.015)是重度甲状腺功能减退症患者发生AKI的预测因子.
■我们建议密切随访和监测由严重甲状腺功能减退引起的AKI患者，如果患者在60岁以上被诊断，CK>1000U/L或FT3<1.3pg/mL。
■这项回顾性观察性研究涉及原发性甲状腺功能减退症和促甲状腺激素（TSH）水平超过50mIU/L的患者，2015年1月至2021年4月。Logistic回归分析影响AKI发生发展的因素。
■总共100名患者，20（11名男性（M），9名女性（F））在AKI（病例）组中和80（23M，57F）对照组患者，包括在我们的研究中。病例组的中位年龄(56岁，四分位距（IQR）44.3-68.5）显着高于对照组（49岁，IQR32.3-60；p=0.027），病例组男女比例明显较高(p=0.001)。多因素logistic回归分析显示，60岁后诊断为甲状腺功能减退（比值比（OR）59.674，95％置信区间（CI）5.955-598.031;p=0.001），游离三碘甲状腺原氨酸(FT3)<1.3pg/mL(OR17.151,95%CI2.491-118.089;p=0.004)和肌酸激酶(CK)>1000U/L(OR1.522,95%CI1.602-82.848;p=0.015)是重度甲状腺功能减退症患者发生AKI的预测因子.
■我们建议密切随访和监测由严重甲状腺功能减退引起的AKI患者，如果患者在60岁以上被诊断，CK>1000U/L或FT3<1.3pg/mL。
