PDF(Pubmed)
Abstract：
UNASSIGNED: Despite the need, measuring glomerular filtration rate (mGFR) is not routinely performed for adults with cerebral palsy (CP), possibly due to unknown feasibility given the secondary complications of CP. This study aimed to assess the feasibility and reliability of mGFR and explore factors associated with eGFR-mGFR discordance among young adults with mild-to-moderate CP.
UNASSIGNED: This single-center, cross-sectional study included 18- to 40-year-olds with CP gross motor function classification system (GMFCS) I-III. The participants were excluded if they were pregnant/lactating, had cognitive impairments, or had contraindications to mGFR. A routine clinical protocol for mGFR and eGFR was used. mGFR feasibility was assessed based on the number of participants who completed testing. mGFR reliability was assessed using the coefficient of variation (CV) across the four 30 min intervals. The association between age, sex, and GMFCS and the percentage of eGFR-mGFR discordance was assessed.
UNASSIGNED: Of the 19 participants enrolled, 18 completed the testing [mean age (SD), 29.9 (7.4) years, n = 10 female participants, n = 10/3/5 for GMFCS I/II/III] and most (n = 15) of the participants had an mGFR >90 mL/min; 14 participants (77.8%) had a CV <20%, 2 had a CV between 20 and 25%, and 2 had a CV >50%. eGFR overestimated mGFR by a median (interquartile range) of approximately 17.5% (2-38%); the full range of mis-estimation was -20.5 to 174.3%. Increasing age and GMFCS levels exhibited notable, but weak-to-modest, associations with a larger eGFR-mGFR discordance.
UNASSIGNED: Obtaining mGFR was feasible and reasonably reliable within this small sample. eGFR overestimated mGFR by a notable amount, which may be associated with patient-level factors.
UNASSIGNED: This single-center, cross-sectional study included 18- to 40-year-olds with CP gross motor function classification system (GMFCS) I-III. The participants were excluded if they were pregnant/lactating, had cognitive impairments, or had contraindications to mGFR. A routine clinical protocol for mGFR and eGFR was used. mGFR feasibility was assessed based on the number of participants who completed testing. mGFR reliability was assessed using the coefficient of variation (CV) across the four 30 min intervals. The association between age, sex, and GMFCS and the percentage of eGFR-mGFR discordance was assessed.
UNASSIGNED: Of the 19 participants enrolled, 18 completed the testing [mean age (SD), 29.9 (7.4) years, n = 10 female participants, n = 10/3/5 for GMFCS I/II/III] and most (n = 15) of the participants had an mGFR >90 mL/min; 14 participants (77.8%) had a CV <20%, 2 had a CV between 20 and 25%, and 2 had a CV >50%. eGFR overestimated mGFR by a median (interquartile range) of approximately 17.5% (2-38%); the full range of mis-estimation was -20.5 to 174.3%. Increasing age and GMFCS levels exhibited notable, but weak-to-modest, associations with a larger eGFR-mGFR discordance.
UNASSIGNED: Obtaining mGFR was feasible and reasonably reliable within this small sample. eGFR overestimated mGFR by a notable amount, which may be associated with patient-level factors.
摘要：
■尽管需要,对于患有脑瘫（CP）的成年人，不常规进行肾小球滤过率（mGFR）的测量，考虑到CP的继发性并发症，可能是可行性未知。本研究旨在评估mGFR的可行性和可靠性，并探讨与轻度至中度CP的年轻成年人eGFR-mGFR不一致相关的因素。
■这个单中心，横断面研究包括18至40岁的CP粗大运动功能分类系统（GMFCS）I-III。如果参与者怀孕/哺乳，则被排除在外。有认知障碍，或有mGFR禁忌症。使用mGFR和eGFR的常规临床方案。mGFR可行性根据完成测试的参与者数量进行评估。使用四个30分钟间隔的变异系数(CV)评估mGFR可靠性。年龄之间的关联，性别,评估GMFCS和eGFR-mGFR不一致的百分比。
■在19名参与者中，18人完成了测试[平均年龄(SD)，29.9（7.4）年，n=10名女性参与者，对于GMFCSI/II/III，n=10/3/5]，大多数（n=15）参与者的mGFR>90mL/min；14名参与者（77.8％）的CV<20％，2的CV在20％至25％之间，2的CV>50%。eGFR高估了mGFR的中位数（四分位数范围）约为17.5％（2-38％）；错误估计的全部范围为-20.5至174.3％。年龄增长和GMFCS水平显著，但是虚弱到谦虚，与更大的eGFR-mGFR不一致的关联。
■在这个小样本中获得mGFR是可行的且合理可靠的。eGFR高估了mGFR，这可能与患者水平的因素有关。
■这个单中心，横断面研究包括18至40岁的CP粗大运动功能分类系统（GMFCS）I-III。如果参与者怀孕/哺乳，则被排除在外。有认知障碍，或有mGFR禁忌症。使用mGFR和eGFR的常规临床方案。mGFR可行性根据完成测试的参与者数量进行评估。使用四个30分钟间隔的变异系数(CV)评估mGFR可靠性。年龄之间的关联，性别,评估GMFCS和eGFR-mGFR不一致的百分比。
■在19名参与者中，18人完成了测试[平均年龄(SD)，29.9（7.4）年，n=10名女性参与者，对于GMFCSI/II/III，n=10/3/5]，大多数（n=15）参与者的mGFR>90mL/min；14名参与者（77.8％）的CV<20％，2的CV在20％至25％之间，2的CV>50%。eGFR高估了mGFR的中位数（四分位数范围）约为17.5％（2-38％）；错误估计的全部范围为-20.5至174.3％。年龄增长和GMFCS水平显著，但是虚弱到谦虚，与更大的eGFR-mGFR不一致的关联。
■在这个小样本中获得mGFR是可行的且合理可靠的。eGFR高估了mGFR，这可能与患者水平的因素有关。
