PDF(Pubmed)
Abstract：
Alzheimer\'s disease (AD) is a devastating neurodegenerative condition with unknown etiology and no cure. Therefore, it is imperative to learn more about the underlying risk factors. Since AD is an age-related disease, one approach is to look at factors associated with aging. One example is sleep disruption, which increases with age and accelerates the progression of cognitive decline. However, some people with sleep loss experience little or no cognitive impairment and are considered resilient. The concept that resilience to sleep disruption increases resistance to AD can be modeled in aging mice with or without cognitive impairment to determine resistance or susceptibility to AD. Given that sleep disruption is a relevant and rising health concern, it is essential to gain a better understanding of resilience, and factors associated with resistance to AD, in order to develop successful intervention strategies.
摘要：
阿尔茨海默病(AD)是一种病因不明、无法治愈的毁灭性神经退行性疾病。因此,必须更多地了解潜在的风险因素。由于AD是一种与年龄有关的疾病，一种方法是研究与衰老相关的因素。一个例子是睡眠中断，随着年龄的增长，并加速认知衰退的进程。然而,一些睡眠不足的人很少或没有认知障碍，被认为是有弹性的。对睡眠中断的复原力增加对AD的抗性的概念可以在具有或不具有认知障碍的衰老小鼠中建模以确定对AD的抗性或易感性。鉴于睡眠中断是一个相关且不断上升的健康问题，对韧性有更好的理解是至关重要的，以及与抗AD相关的因素，以制定成功的干预策略。
