PDF(Pubmed)
Abstract：
UNASSIGNED: In this extensive review work, the important role of AMP-activated protein kinase (AMPK) in causing of diabetes mellitus has been highlighted. Structural feature of AMPK as well its regulations and roles are described nicely, and the association of AMPK with the diabetic complications like nephropathy, neuropathy and retinopathy are also explained along with the connection between AMPK and β-cell function, insulin resistivity, mTOR, protein metabolism, autophagy and mitophagy and effect on protein and lipid metabolism.
UNASSIGNED: Published journals were searched on the database like PubMed, Medline, Scopus and Web of Science by using keywords such as AMPK, diabetes mellitus, regulation of AMPK, complications of diabetes mellitus, autophagy, apoptosis etc.
UNASSIGNED: After extensive review, it has been found that, kinase enzyme like AMPK is having vital role in management of type II diabetes mellitus. AMPK involve in enhance the concentration of glucose transporter like GLUT 1 and GLUT 4 which result in lowering of blood glucose level in influx of blood glucose into the cells; AMPK increases the insulin sensitivity and decreases the insulin resistance and further AMPK decreases the apoptosis of β-cells which result into secretion of insulin and AMPK is also involve in declining of oxidative stress, lipotoxicity and inflammation, owing to which organ damage due to diabetes mellitus can be lowered by activation of AMPK.
UNASSIGNED: As AMPK activation leads to overall control of diabetes mellitus, designing and developing of small molecules or peptide that can act as AMPK agonist will be highly beneficial for control or manage diabetes mellitus.
UNASSIGNED: Published journals were searched on the database like PubMed, Medline, Scopus and Web of Science by using keywords such as AMPK, diabetes mellitus, regulation of AMPK, complications of diabetes mellitus, autophagy, apoptosis etc.
UNASSIGNED: After extensive review, it has been found that, kinase enzyme like AMPK is having vital role in management of type II diabetes mellitus. AMPK involve in enhance the concentration of glucose transporter like GLUT 1 and GLUT 4 which result in lowering of blood glucose level in influx of blood glucose into the cells; AMPK increases the insulin sensitivity and decreases the insulin resistance and further AMPK decreases the apoptosis of β-cells which result into secretion of insulin and AMPK is also involve in declining of oxidative stress, lipotoxicity and inflammation, owing to which organ damage due to diabetes mellitus can be lowered by activation of AMPK.
UNASSIGNED: As AMPK activation leads to overall control of diabetes mellitus, designing and developing of small molecules or peptide that can act as AMPK agonist will be highly beneficial for control or manage diabetes mellitus.
摘要：
■在这项广泛的审查工作中，AMP激活的蛋白激酶（AMPK）在糖尿病中的重要作用已被强调。很好地描述了AMPK的结构特征及其调控和作用，以及AMPK与糖尿病并发症如肾病的关系，神经病变和视网膜病变以及AMPK和β细胞功能之间的联系也被解释，胰岛素电阻率，mTOR,蛋白质代谢，自噬和线粒体自噬对蛋白质和脂质代谢的影响。
■在数据库中搜索已发布的期刊，例如PubMed，Medline,Scopus和WebofScience通过使用AMPK等关键字，糖尿病,AMPK的调节，糖尿病并发症,自噬,凋亡等.
■经过广泛的审查，已经发现,AMPK等激酶在II型糖尿病的治疗中起着至关重要的作用。AMPK参与增加葡萄糖转运蛋白的浓度，如GLUT1和GLUT4，导致血糖水平降低，在血糖流入细胞中；AMPK增加胰岛素敏感性，降低胰岛素抵抗，进一步AMPK减少β细胞凋亡，导致胰岛素分泌，AMPK也参与氧化应激的下降。脂毒性和炎症，因此，通过激活AMPK可以降低糖尿病引起的器官损伤。
■由于AMPK激活导致糖尿病的全面控制，设计和开发可以作为AMPK激动剂的小分子或肽对于控制或管理糖尿病将是非常有益的。
■在数据库中搜索已发布的期刊，例如PubMed，Medline,Scopus和WebofScience通过使用AMPK等关键字，糖尿病,AMPK的调节，糖尿病并发症,自噬,凋亡等.
■经过广泛的审查，已经发现,AMPK等激酶在II型糖尿病的治疗中起着至关重要的作用。AMPK参与增加葡萄糖转运蛋白的浓度，如GLUT1和GLUT4，导致血糖水平降低，在血糖流入细胞中；AMPK增加胰岛素敏感性，降低胰岛素抵抗，进一步AMPK减少β细胞凋亡，导致胰岛素分泌，AMPK也参与氧化应激的下降。脂毒性和炎症，因此，通过激活AMPK可以降低糖尿病引起的器官损伤。
■由于AMPK激活导致糖尿病的全面控制，设计和开发可以作为AMPK激动剂的小分子或肽对于控制或管理糖尿病将是非常有益的。
