UNASSIGNED: Published journals were searched on the database like PubMed, Medline, Scopus and Web of Science by using keywords such as AMPK, diabetes mellitus, regulation of AMPK, complications of diabetes mellitus, autophagy, apoptosis etc.
UNASSIGNED: After extensive review, it has been found that, kinase enzyme like AMPK is having vital role in management of type II diabetes mellitus. AMPK involve in enhance the concentration of glucose transporter like GLUT 1 and GLUT 4 which result in lowering of blood glucose level in influx of blood glucose into the cells; AMPK increases the insulin sensitivity and decreases the insulin resistance and further AMPK decreases the apoptosis of β-cells which result into secretion of insulin and AMPK is also involve in declining of oxidative stress, lipotoxicity and inflammation, owing to which organ damage due to diabetes mellitus can be lowered by activation of AMPK.
UNASSIGNED: As AMPK activation leads to overall control of diabetes mellitus, designing and developing of small molecules or peptide that can act as AMPK agonist will be highly beneficial for control or manage diabetes mellitus.
■在数据库中搜索已发布的期刊,例如PubMed,Medline,Scopus和WebofScience通过使用AMPK等关键字,糖尿病,AMPK的调节,糖尿病并发症,自噬,凋亡等.
■经过广泛的审查,已经发现,AMPK等激酶在II型糖尿病的治疗中起着至关重要的作用。AMPK参与增加葡萄糖转运蛋白的浓度,如GLUT1和GLUT4,导致血糖水平降低,在血糖流入细胞中;AMPK增加胰岛素敏感性,降低胰岛素抵抗,进一步AMPK减少β细胞凋亡,导致胰岛素分泌,AMPK也参与氧化应激的下降。脂毒性和炎症,因此,通过激活AMPK可以降低糖尿病引起的器官损伤。
■由于AMPK激活导致糖尿病的全面控制,设计和开发可以作为AMPK激动剂的小分子或肽对于控制或管理糖尿病将是非常有益的。