PDF(Pubmed)
Abstract：
UNASSIGNED: To compare the changes in body weight and glycemic control before and during the COVID-19 pandemic in people with type 1 diabetes (T1D).
UNASSIGNED: In 47,065 individuals with T1D from the German Diabetes Prospective Follow-up Registry (DPV), we compared the adjusted mean changes in BMI-Z-scores and HbA1c as well as the distribution of individual changes between four periods from March 2018 to February 2022, by sex and age group (4- < 11, 11- < 16, 16-50 years).
UNASSIGNED: At population level, the only significant pandemic effects were a slight increase in BMI Z-score in prepubertal children (girls: + 0.03 in the first COVID year vs. before, P < 0.01; boys: + 0.04, P < 0.01) as well as a stabilization of HbA1c in all subgroups or even improvement in women (- 0.08%, P < 0.01). At individual level, however, heterogeneity increased significantly (p < 0.01), especially in children. More prepubertal children gained weight (girls: 45% vs. 35% before COVID; boys: 39% vs. 33%). More pubertal girls lost weight (30% vs. 21%) and fewer gained weight (43% vs. 54%). More children had a decreasing HbA1c (prepubertal group: 29% vs. 22%; pubertal girls: 33% vs. 28%; pubertal boys: 32% vs. 25%) and fewer had increasing values. More women had stable HbA1c and fewer had increasing values (30% vs. 37%). In men, no significant changes were observed.
UNASSIGNED: This real-world analysis shows no detrimental consequences of the two first COVID years on weight and HbA1c in T1D on average, but reveals, beyond the mean trends, a greater variability at the individual level.
UNASSIGNED: In 47,065 individuals with T1D from the German Diabetes Prospective Follow-up Registry (DPV), we compared the adjusted mean changes in BMI-Z-scores and HbA1c as well as the distribution of individual changes between four periods from March 2018 to February 2022, by sex and age group (4- < 11, 11- < 16, 16-50 years).
UNASSIGNED: At population level, the only significant pandemic effects were a slight increase in BMI Z-score in prepubertal children (girls: + 0.03 in the first COVID year vs. before, P < 0.01; boys: + 0.04, P < 0.01) as well as a stabilization of HbA1c in all subgroups or even improvement in women (- 0.08%, P < 0.01). At individual level, however, heterogeneity increased significantly (p < 0.01), especially in children. More prepubertal children gained weight (girls: 45% vs. 35% before COVID; boys: 39% vs. 33%). More pubertal girls lost weight (30% vs. 21%) and fewer gained weight (43% vs. 54%). More children had a decreasing HbA1c (prepubertal group: 29% vs. 22%; pubertal girls: 33% vs. 28%; pubertal boys: 32% vs. 25%) and fewer had increasing values. More women had stable HbA1c and fewer had increasing values (30% vs. 37%). In men, no significant changes were observed.
UNASSIGNED: This real-world analysis shows no detrimental consequences of the two first COVID years on weight and HbA1c in T1D on average, but reveals, beyond the mean trends, a greater variability at the individual level.
摘要：
■比较1型糖尿病（T1D）患者在COVID-19大流行之前和期间的体重和血糖控制变化。
■在来自德国糖尿病前瞻性随访注册（DPV）的47,065名T1D患者中，我们比较了2018年3月至2022年2月4个时期的BMI-Z评分和HbA1c的校正平均变化,以及按性别和年龄组(4-<11,11-<16,16-50岁)的个体变化分布.
■在人口水平上，唯一显著的大流行效应是青春期前儿童的BMIZ评分略有增加(女孩：在第一个COVID年为+0.03，而不是之前，P<0.01；男孩：0.04，P<0.01）以及所有亚组的HbA1c稳定，甚至女性改善（-0.08％，P<0.01)。在个人层面,然而,异质性显著增加(p<0.01)，尤其是儿童。更多的青春期前儿童体重增加（女孩：45％vs.COVID前35%；男孩：39%33%）。更多青春期女孩体重减轻（30％vs.21%）和较少的体重增加（43%vs.54%）。更多儿童的HbA1c下降（青春期前组：29％vs.22％;青春期女孩：33％vs.28％;青春期男孩：32％vs.25%)和更少的有递增值。更多的女性有稳定的HbA1c，更少的女性有增加的值(30%vs.37%）。在男人中，没有观察到显著的变化。
■这项现实世界的分析显示，前两个COVID年对T1D的平均体重和HbA1c没有不利影响，但揭示了，超越平均趋势，在个人层面上有更大的可变性。
■在来自德国糖尿病前瞻性随访注册（DPV）的47,065名T1D患者中，我们比较了2018年3月至2022年2月4个时期的BMI-Z评分和HbA1c的校正平均变化,以及按性别和年龄组(4-<11,11-<16,16-50岁)的个体变化分布.
■在人口水平上，唯一显著的大流行效应是青春期前儿童的BMIZ评分略有增加(女孩：在第一个COVID年为+0.03，而不是之前，P<0.01；男孩：0.04，P<0.01）以及所有亚组的HbA1c稳定，甚至女性改善（-0.08％，P<0.01)。在个人层面,然而,异质性显著增加(p<0.01)，尤其是儿童。更多的青春期前儿童体重增加（女孩：45％vs.COVID前35%；男孩：39%33%）。更多青春期女孩体重减轻（30％vs.21%）和较少的体重增加（43%vs.54%）。更多儿童的HbA1c下降（青春期前组：29％vs.22％;青春期女孩：33％vs.28％;青春期男孩：32％vs.25%)和更少的有递增值。更多的女性有稳定的HbA1c，更少的女性有增加的值(30%vs.37%）。在男人中，没有观察到显著的变化。
■这项现实世界的分析显示，前两个COVID年对T1D的平均体重和HbA1c没有不利影响，但揭示了，超越平均趋势，在个人层面上有更大的可变性。
