PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetes mellitus [DM], is a multifaceted metabolic disease, which has become a worldwide threat to human wellness. Over the past decades, an enormous amount of attention has been devoted to understanding how microRNAs [miRNAs], a class of small non-coding RNA regulators of gene expression at the post-transcriptional level, are tied to DM pathology. It has been demonstrated that miRNAs control insulin synthesis, secretion, and activity. This review aims to provide an evaluation of the use of miR-143 and miR-145 as biomarkers for the diagnosis and prognosis of diabetes.
UNASSIGNED: The use of miR-143 and miR-145 as biomarkers for the diagnosis and prognosis of diabetes has been studied, and research that examined this link was sought after in the literature. In addition, we will discuss the cellular and molecular pathways of insulin secretion regulation by miR-143/145 expression and finally their role in diabetes.
UNASSIGNED: In the current review, we emphasize recent findings on the miR-143/145 expression profiles as novel DM biomarkers in clinical studies and animal models and highlight recent discoveries on the complex regulatory effect and functional role of miR-143/145 expression in DM.
UNASSIGNED: A novel clinical treatment that alters the expression and activity of miR-143/miR-145 may be able to return cells to their natural state of glucose homeostasis, demonstrating the value of using comprehensive miRNA profiles to predict the beginning of diabetes.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s40200-023-01317-y.
UNASSIGNED: The use of miR-143 and miR-145 as biomarkers for the diagnosis and prognosis of diabetes has been studied, and research that examined this link was sought after in the literature. In addition, we will discuss the cellular and molecular pathways of insulin secretion regulation by miR-143/145 expression and finally their role in diabetes.
UNASSIGNED: In the current review, we emphasize recent findings on the miR-143/145 expression profiles as novel DM biomarkers in clinical studies and animal models and highlight recent discoveries on the complex regulatory effect and functional role of miR-143/145 expression in DM.
UNASSIGNED: A novel clinical treatment that alters the expression and activity of miR-143/miR-145 may be able to return cells to their natural state of glucose homeostasis, demonstrating the value of using comprehensive miRNA profiles to predict the beginning of diabetes.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s40200-023-01317-y.
摘要：
■糖尿病[DM]，是一种多方面的代谢疾病，这已经成为对人类健康的全球性威胁。在过去的几十年里，大量的注意力已经致力于理解microRNAs[miRNAs]，一类在转录后水平的基因表达的小的非编码RNA调节因子，与DM病理学有关。已经证明miRNAs控制胰岛素合成，分泌，和活动。本综述旨在评估miR-143和miR-145作为糖尿病诊断和预后的生物标志物。
■已经研究了使用miR-143和miR-145作为糖尿病诊断和预后的生物标志物，研究这种联系的研究在文献中得到了追捧。此外,我们将讨论通过miR-143/145表达调节胰岛素分泌的细胞和分子途径，最后讨论它们在糖尿病中的作用。
■在当前的评论中，我们强调了miR-143/145表达谱在临床研究和动物模型中作为新型DM生物标志物的最新发现,并强调了miR-143/145表达在DM中的复杂调节作用和功能作用的最新发现.
■一种改变miR-143/miR-145的表达和活性的新型临床治疗方法可能能够使细胞恢复其自然状态的葡萄糖稳态。证明了使用全面的miRNA谱预测糖尿病开始的价值。
■在线版本包含补充材料，可在10.1007/s40200-023-01317-y获得。
■已经研究了使用miR-143和miR-145作为糖尿病诊断和预后的生物标志物，研究这种联系的研究在文献中得到了追捧。此外,我们将讨论通过miR-143/145表达调节胰岛素分泌的细胞和分子途径，最后讨论它们在糖尿病中的作用。
■在当前的评论中，我们强调了miR-143/145表达谱在临床研究和动物模型中作为新型DM生物标志物的最新发现,并强调了miR-143/145表达在DM中的复杂调节作用和功能作用的最新发现.
■一种改变miR-143/miR-145的表达和活性的新型临床治疗方法可能能够使细胞恢复其自然状态的葡萄糖稳态。证明了使用全面的miRNA谱预测糖尿病开始的价值。
■在线版本包含补充材料，可在10.1007/s40200-023-01317-y获得。
