PDF(Pubmed)
Abstract：
UNASSIGNED: Emerging publications indicate that diabetes predisposes patients with COVID-19 to more severe complications, which is partly attributed to inflammatory condition. In the current review, we reviewed recent published literature to provide evidence on the role of insulin resistance (IR) in diabetes, the association between diabetes and COVID-19 severity and mortality, the impact of COVID-19 infection on incident new-onset diabetes, mechanisms responsible for IR in COVID-19 patients, and the predictive value of different surrogates of IR in COVID-19.
UNASSIGNED: The literature search performs to find out studies that have assessed the association between IR surrogates and morbidity and mortality in patients with COVID-19.
UNASSIGNED: We showed that there is a bulk of evidence in support of the fact that diabetes is a potent risk factor for enhanced morbidity and mortality in COVID-19 patients. COVID-19 patients with diabetes are more prone to remarkable dysglycemia compared to those without diabetes, which is associated with an unfavourable prognosis. Furthermore, SARS-COV2 can make patients predispose to IR and diabetes via activating ISR, affecting RAAS signaling pathway, provoking inflammation, and changing the expression of PPARɣ and SREBP-1. Additionally, higher IR is associated with increased morbidity and mortality in COVID-19 patients and different surrogates of IR can be utilized as a prognostic biomarker for COVID-19 patients.
UNASSIGNED: Different surrogates of IR can be utilized as predictors of COVID-19 complications and death.
UNASSIGNED: The literature search performs to find out studies that have assessed the association between IR surrogates and morbidity and mortality in patients with COVID-19.
UNASSIGNED: We showed that there is a bulk of evidence in support of the fact that diabetes is a potent risk factor for enhanced morbidity and mortality in COVID-19 patients. COVID-19 patients with diabetes are more prone to remarkable dysglycemia compared to those without diabetes, which is associated with an unfavourable prognosis. Furthermore, SARS-COV2 can make patients predispose to IR and diabetes via activating ISR, affecting RAAS signaling pathway, provoking inflammation, and changing the expression of PPARɣ and SREBP-1. Additionally, higher IR is associated with increased morbidity and mortality in COVID-19 patients and different surrogates of IR can be utilized as a prognostic biomarker for COVID-19 patients.
UNASSIGNED: Different surrogates of IR can be utilized as predictors of COVID-19 complications and death.
摘要：
■新兴出版物表明，糖尿病使COVID-19患者容易出现更严重的并发症，部分归因于炎症。在当前的审查中，我们回顾了最近发表的文献，以提供胰岛素抵抗（IR）在糖尿病中的作用的证据，糖尿病与COVID-19严重程度和死亡率之间的关系，COVID-19感染对新发糖尿病的影响，COVID-19患者IR的机制，以及不同替代IR对COVID-19的预测价值。
■文献检索旨在找出评估IR替代与COVID-19患者发病率和死亡率之间关系的研究。
■我们表明，有大量证据支持以下事实：糖尿病是COVID-19患者发病率和死亡率增加的有效危险因素。与没有糖尿病的患者相比，患有糖尿病的COVID-19患者更容易出现明显的血糖异常，这与不利的预后有关。此外，SARS-COV2可以通过激活ISR使患者易患IR和糖尿病，影响RAAS信号通路，引起炎症，改变PPAR和SREBP-1的表达。此外,较高的IR与COVID-19患者的发病率和死亡率增加相关,不同的IR替代指标可作为COVID-19患者的预后生物标志物.
■IR的不同替代指标可用作COVID-19并发症和死亡的预测因子。
■文献检索旨在找出评估IR替代与COVID-19患者发病率和死亡率之间关系的研究。
■我们表明，有大量证据支持以下事实：糖尿病是COVID-19患者发病率和死亡率增加的有效危险因素。与没有糖尿病的患者相比，患有糖尿病的COVID-19患者更容易出现明显的血糖异常，这与不利的预后有关。此外，SARS-COV2可以通过激活ISR使患者易患IR和糖尿病，影响RAAS信号通路，引起炎症，改变PPAR和SREBP-1的表达。此外,较高的IR与COVID-19患者的发病率和死亡率增加相关,不同的IR替代指标可作为COVID-19患者的预后生物标志物.
■IR的不同替代指标可用作COVID-19并发症和死亡的预测因子。
