PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetes is a growing metabolic disease that is characterized by high blood sugar levels with life-threatening results. Diabetic wounds are a major problem because they do not resolve in few days. Major problems affecting wound healing are infection, age, stress, etc. at the wound site, and other associated disease conditions. Lycopene is a red pigment obtained from various fruits such as tomatoes, watermelon, and guava. It is a powerful antioxidant that scavenges reactive oxygen species and potential as nutraceuticals. It has reported antidiabetic, antioxidant, anti-obesity, anti-inflammatory, antihyperglycemic, and antiaging activities based on the literature.
UNASSIGNED: The objective of the current study is to find the wound-healing potential of lycopene emulgel (LE) and report the properties of the compound.
UNASSIGNED: Wound healing activity was assessed in Streptozotocin induced diabetic rats and control rats. Streptozotocin injection (55 mg/kg) was used to induce marked hyperglycaemia, compared with controls. The formulation was applied topically and was evaluated for efficacy.
UNASSIGNED: Treatment of rats with lycopene emulgel (LE) topical application exhibited a significant reduction of wound closure of 95.3 and 88.9% and epithelisation within 21 days.
UNASSIGNED: The formulation was found to be novel, safe, and effective in the functional recovery of wounds.
UNASSIGNED: The objective of the current study is to find the wound-healing potential of lycopene emulgel (LE) and report the properties of the compound.
UNASSIGNED: Wound healing activity was assessed in Streptozotocin induced diabetic rats and control rats. Streptozotocin injection (55 mg/kg) was used to induce marked hyperglycaemia, compared with controls. The formulation was applied topically and was evaluated for efficacy.
UNASSIGNED: Treatment of rats with lycopene emulgel (LE) topical application exhibited a significant reduction of wound closure of 95.3 and 88.9% and epithelisation within 21 days.
UNASSIGNED: The formulation was found to be novel, safe, and effective in the functional recovery of wounds.
摘要：
糖尿病是一种不断增长的代谢性疾病，其特征是高血糖水平会危及生命。糖尿病伤口是一个主要问题，因为它们不会在几天内解决。影响伤口愈合的主要问题是感染，年龄,压力，等。在伤口部位，和其他相关疾病。番茄红素是一种从各种水果如西红柿中获得的红色色素，西瓜,还有番石榴.它是一种强大的抗氧化剂，可清除活性氧，并具有作为营养食品的潜力。它报道了抗糖尿病药，抗氧化剂，抗肥胖,抗炎,抗高血糖,和基于文献的抗衰老活性。
■当前研究的目的是发现番茄红素乳化剂（LE）的伤口愈合潜力，并报告该化合物的性质。
在链脲佐菌素诱导的糖尿病大鼠和对照大鼠中评估伤口愈合活性。链脲佐菌素注射液（55mg/kg）用于诱导明显的高血糖，与对照组相比。局部施用该制剂并评价其功效。
用番茄红素乳化凝胶(LE)局部应用治疗大鼠在21天内表现出95.3和88.9%的伤口闭合和上皮形成的显著减少。
■发现该配方是新颖的，安全,对伤口的功能恢复有效。
■当前研究的目的是发现番茄红素乳化剂（LE）的伤口愈合潜力，并报告该化合物的性质。
在链脲佐菌素诱导的糖尿病大鼠和对照大鼠中评估伤口愈合活性。链脲佐菌素注射液（55mg/kg）用于诱导明显的高血糖，与对照组相比。局部施用该制剂并评价其功效。
用番茄红素乳化凝胶(LE)局部应用治疗大鼠在21天内表现出95.3和88.9%的伤口闭合和上皮形成的显著减少。
■发现该配方是新颖的，安全,对伤口的功能恢复有效。
