PDF(Pubmed)
Abstract：
UNASSIGNED: Baseline mapping showed that schistosomiasis was highly/moderately endemic in nine districts in Sierra Leone. Mass drug administration (MDA) with praziquantel started in 2009, and after multiple rounds of treatment, an impact assessment was conducted in 2016 followed by a second re-assessment in 2022 using cluster sampling to provide more granular data for refining chiefdom (sub-district) treatment strategies.
UNASSIGNED: On average, 20 rural villages were systematically selected per district by probability proportional to population size across the nine districts. Surveys were conducted in schools, and 24 school children aged between 5 and 14 years were randomly selected, with an equal number of boys and girls. One stool sample and one urine sample were collected per child. Two Kato-Katz slides were examined per stool for Schistosoma mansoni infection. Hemastix strips were used as a proxy for S. haematobium infection with urine filtration used for egg counts on hematuria-positive samples.
UNASSIGNED: In total, 4,736 stool samples and 4,618 urine samples were examined across 200 schools in 125 chiefdoms. Overall, the prevalence of S. mansoni was 16.3% (95% CI: 15.3-17.4%), while the overall prevalence of S. haematobium was 2.0% (95% CI: 1.6-2.4%) by hematuria. The prevalence of heavy infections for S. mansoni and S. haematobium was 1.5% (95% CI: 1.1-1.9%) and 0.02% (95% CI: 0.0-0.14%), respectively. Among 125 chiefdoms surveyed, the overall schistosomiasis prevalence was <10% in 65 chiefdoms, 10-49.9% in 47 chiefdoms, and ≥ 50% in 13 chiefdoms. There was a mixed relationship between schistosomiasis in school children and WASH access in schools.
UNASSIGNED: Sierra Leone has made significant progress in reducing schistosomiasis prevalence across the country after a decade of MDA intervention. However, high prevalence remains in some hotspot chiefdoms. The next steps are for the national program to investigate and address any potential issues such as low coverage or poor knowledge of schistosomiasis risk behaviors and, where appropriate, consider broadening to community-wide treatment in hotspot chiefdoms or communities.
UNASSIGNED: On average, 20 rural villages were systematically selected per district by probability proportional to population size across the nine districts. Surveys were conducted in schools, and 24 school children aged between 5 and 14 years were randomly selected, with an equal number of boys and girls. One stool sample and one urine sample were collected per child. Two Kato-Katz slides were examined per stool for Schistosoma mansoni infection. Hemastix strips were used as a proxy for S. haematobium infection with urine filtration used for egg counts on hematuria-positive samples.
UNASSIGNED: In total, 4,736 stool samples and 4,618 urine samples were examined across 200 schools in 125 chiefdoms. Overall, the prevalence of S. mansoni was 16.3% (95% CI: 15.3-17.4%), while the overall prevalence of S. haematobium was 2.0% (95% CI: 1.6-2.4%) by hematuria. The prevalence of heavy infections for S. mansoni and S. haematobium was 1.5% (95% CI: 1.1-1.9%) and 0.02% (95% CI: 0.0-0.14%), respectively. Among 125 chiefdoms surveyed, the overall schistosomiasis prevalence was <10% in 65 chiefdoms, 10-49.9% in 47 chiefdoms, and ≥ 50% in 13 chiefdoms. There was a mixed relationship between schistosomiasis in school children and WASH access in schools.
UNASSIGNED: Sierra Leone has made significant progress in reducing schistosomiasis prevalence across the country after a decade of MDA intervention. However, high prevalence remains in some hotspot chiefdoms. The next steps are for the national program to investigate and address any potential issues such as low coverage or poor knowledge of schistosomiasis risk behaviors and, where appropriate, consider broadening to community-wide treatment in hotspot chiefdoms or communities.
摘要：
■基线制图显示，血吸虫病在塞拉利昂9个地区高度/中度流行。2009年开始使用吡喹酮进行大规模药物治疗（MDA），经过多轮治疗，我们在2016年进行了影响评估,随后在2022年采用整群抽样进行了第二次重新评估,为完善cheefdom(分区)治疗策略提供更细粒度的数据.
■平均而言，每个地区按与9个地区的人口规模成正比的概率系统地选择了20个农村村庄。调查是在学校进行的，随机抽取24名年龄在5至14岁之间的学童，男孩和女孩的数量相等。每个儿童收集一个粪便样本和一个尿液样本。每个粪便检查了两个Kato-Katz载玻片是否感染曼氏血吸虫。使用Hemastix条带作为血尿阳性样品的卵计数的尿液过滤的替代。
■总共，在125个酋长领地的200所学校中检查了4,736个粪便样本和4,618个尿液样本。总的来说,曼氏链球菌的患病率为16.3%(95%CI:15.3-17.4%)，而血尿的总患病率为2.0％（95％CI：1.6-2.4％）。MansoniS.和HematobiumS.重型感染的患病率分别为1.5％（95％CI：1.1-1.9％）和0.02％（95％CI：0.0-0.14％），分别。在接受调查的125个酋长中，在65个土族中，血吸虫病的总体患病率<10％，在47个酋长领地中占10-49.9%，在13个酋长领地中≥50%。学童中的血吸虫病与学校中的WASH接触之间存在混合关系。
■经过十年的MDA干预，塞拉利昂在降低全国血吸虫病患病率方面取得了重大进展。然而,一些热点地区的流行率仍然很高。接下来的步骤是国家计划，以调查和解决任何潜在的问题，例如对血吸虫病风险行为的覆盖率低或知识不足，在适当的情况下，考虑扩大到热点酋长或社区的社区范围治疗。
■平均而言，每个地区按与9个地区的人口规模成正比的概率系统地选择了20个农村村庄。调查是在学校进行的，随机抽取24名年龄在5至14岁之间的学童，男孩和女孩的数量相等。每个儿童收集一个粪便样本和一个尿液样本。每个粪便检查了两个Kato-Katz载玻片是否感染曼氏血吸虫。使用Hemastix条带作为血尿阳性样品的卵计数的尿液过滤的替代。
■总共，在125个酋长领地的200所学校中检查了4,736个粪便样本和4,618个尿液样本。总的来说,曼氏链球菌的患病率为16.3%(95%CI:15.3-17.4%)，而血尿的总患病率为2.0％（95％CI：1.6-2.4％）。MansoniS.和HematobiumS.重型感染的患病率分别为1.5％（95％CI：1.1-1.9％）和0.02％（95％CI：0.0-0.14％），分别。在接受调查的125个酋长中，在65个土族中，血吸虫病的总体患病率<10％，在47个酋长领地中占10-49.9%，在13个酋长领地中≥50%。学童中的血吸虫病与学校中的WASH接触之间存在混合关系。
■经过十年的MDA干预，塞拉利昂在降低全国血吸虫病患病率方面取得了重大进展。然而,一些热点地区的流行率仍然很高。接下来的步骤是国家计划，以调查和解决任何潜在的问题，例如对血吸虫病风险行为的覆盖率低或知识不足，在适当的情况下，考虑扩大到热点酋长或社区的社区范围治疗。
