PDF(Pubmed)
Abstract：
UNASSIGNED: Pollution has emerged as a significant threat to humanity, necessitating a thorough evaluation of its impacts. As a result, various methods for human biomonitoring have been proposed as vital tools for assessing, managing, and mitigating exposure risks. Among these methods, urine stands out as the most commonly analyzed biological sample and the primary matrix for biomonitoring studies.
UNASSIGNED: This review concentrates on exploring the literature concerning residual pesticide determination in urine, utilizing liquid and gas chromatography coupled with mass spectrometry, and its practical applications.
UNASSIGNED: The examination focused on methods developed since 2010. Additionally, applications reported between 2015 and 2022 were thoroughly reviewed, utilizing Web of Science as a primary resource.
UNASSIGNED: Recent advancements in chromatography-mass spectrometry technology have significantly enhanced the development of multi-residue methods. These determinations are now capable of simultaneously detecting numerous pesticide residues from various chemical and use classes. Furthermore, these methods encompass analytes from a variety of environmental contaminants, offering a comprehensive approach to biomonitoring. These methodologies have been employed across diverse perspectives, including toxicological studies, assessing pesticide exposure in the general population, occupational exposure among farmers, pest control workers, horticulturists, and florists, as well as investigating consequences during pregnancy and childhood, neurodevelopmental impacts, and reproductive disorders.
UNASSIGNED: Such strategies were essential in examining the health risks associated with exposure to complex mixtures, including pesticides and other relevant compounds, thereby painting a broader and more accurate picture of human exposure. Moreover, the implementation of integrated strategies, involving international research initiatives and biomonitoring programs, is crucial to optimize resource utilization, enhancing efficiency in health risk assessment.
UNASSIGNED: This review concentrates on exploring the literature concerning residual pesticide determination in urine, utilizing liquid and gas chromatography coupled with mass spectrometry, and its practical applications.
UNASSIGNED: The examination focused on methods developed since 2010. Additionally, applications reported between 2015 and 2022 were thoroughly reviewed, utilizing Web of Science as a primary resource.
UNASSIGNED: Recent advancements in chromatography-mass spectrometry technology have significantly enhanced the development of multi-residue methods. These determinations are now capable of simultaneously detecting numerous pesticide residues from various chemical and use classes. Furthermore, these methods encompass analytes from a variety of environmental contaminants, offering a comprehensive approach to biomonitoring. These methodologies have been employed across diverse perspectives, including toxicological studies, assessing pesticide exposure in the general population, occupational exposure among farmers, pest control workers, horticulturists, and florists, as well as investigating consequences during pregnancy and childhood, neurodevelopmental impacts, and reproductive disorders.
UNASSIGNED: Such strategies were essential in examining the health risks associated with exposure to complex mixtures, including pesticides and other relevant compounds, thereby painting a broader and more accurate picture of human exposure. Moreover, the implementation of integrated strategies, involving international research initiatives and biomonitoring programs, is crucial to optimize resource utilization, enhancing efficiency in health risk assessment.
摘要：
■污染已成为对人类的重大威胁，需要对其影响进行彻底评估。因此,人类生物监测的各种方法已被提出作为评估的重要工具，管理,并降低暴露风险。在这些方法中,尿液是最常用的分析生物样本和生物监测研究的主要基质。
■这篇综述集中于探索有关尿液中残留农药测定的文献，利用液相和气相色谱法以及质谱，及其实际应用。
■考试的重点是自2010年以来开发的方法。此外,对2015年至2022年之间报告的申请进行了彻底审查，利用WebofScience作为主要资源。
■色谱-质谱技术的最新进展显着促进了多残基方法的发展。这些测定现在能够同时检测来自各种化学和用途类别的许多农药残留物。此外，这些方法包括来自各种环境污染物的分析物，提供全面的生物监测方法。这些方法已经被用于不同的观点，包括毒理学研究,评估普通人群中的农药暴露，农民的职业暴露，病虫害防治工作者,园艺家,和花店，以及调查怀孕和童年的后果，神经发育影响，和生殖障碍。
■这些策略对于检查与接触复杂混合物相关的健康风险至关重要。包括杀虫剂和其他相关化合物，从而绘制更广泛，更准确的人体暴露图。此外，实施综合战略，涉及国际研究计划和生物监测计划，对优化资源利用至关重要，提高健康风险评估的效率。
■这篇综述集中于探索有关尿液中残留农药测定的文献，利用液相和气相色谱法以及质谱，及其实际应用。
■考试的重点是自2010年以来开发的方法。此外,对2015年至2022年之间报告的申请进行了彻底审查，利用WebofScience作为主要资源。
■色谱-质谱技术的最新进展显着促进了多残基方法的发展。这些测定现在能够同时检测来自各种化学和用途类别的许多农药残留物。此外，这些方法包括来自各种环境污染物的分析物，提供全面的生物监测方法。这些方法已经被用于不同的观点，包括毒理学研究,评估普通人群中的农药暴露，农民的职业暴露，病虫害防治工作者,园艺家,和花店，以及调查怀孕和童年的后果，神经发育影响，和生殖障碍。
■这些策略对于检查与接触复杂混合物相关的健康风险至关重要。包括杀虫剂和其他相关化合物，从而绘制更广泛，更准确的人体暴露图。此外，实施综合战略，涉及国际研究计划和生物监测计划，对优化资源利用至关重要，提高健康风险评估的效率。
