Abstract：
UNASSIGNED: Sleep has important effects on breathing and gas exchange that may have negative consequences in patients with chronic obstructive pulmonary disease (COPD). COPD and obstructive sleep apnea (OSA) are highly prevalent and may coexist, which is referred to as the overlap syndrome.
UNASSIGNED: The probability of OSA-COPD overlap represents the balance of protective and promoting factors such as hyperinflation and fluid retention; thus, different clinical COPD phenotypes influence the likelihood of comorbid OSA. The clinical presentation of OSA-COPD overlap is nonspecific, and the diagnosis requires clinical awareness to identify patients needing overnight studies. Both COPD and OSA are associated with a range of overlapping physiological and biological disturbances including hypoxia and inflammation that contribute to cardiovascular comorbidities. The management of OSA-COPD overlap patients differs from those with COPD alone and the survival of overlap patients treated with positive airway pressure (PAP) is superior to those untreated.
UNASSIGNED: The recognition of OSA-COPD overlap has important clinical relevance because of its impact on outcomes and management. Management of the overlap should address both sleep quality and disordered gas exchange. PAP therapy has demonstrated reductions in COPD exacerbations, hospitalizations, healthcare costs and mortality in overlap patients.
UNASSIGNED: The probability of OSA-COPD overlap represents the balance of protective and promoting factors such as hyperinflation and fluid retention; thus, different clinical COPD phenotypes influence the likelihood of comorbid OSA. The clinical presentation of OSA-COPD overlap is nonspecific, and the diagnosis requires clinical awareness to identify patients needing overnight studies. Both COPD and OSA are associated with a range of overlapping physiological and biological disturbances including hypoxia and inflammation that contribute to cardiovascular comorbidities. The management of OSA-COPD overlap patients differs from those with COPD alone and the survival of overlap patients treated with positive airway pressure (PAP) is superior to those untreated.
UNASSIGNED: The recognition of OSA-COPD overlap has important clinical relevance because of its impact on outcomes and management. Management of the overlap should address both sleep quality and disordered gas exchange. PAP therapy has demonstrated reductions in COPD exacerbations, hospitalizations, healthcare costs and mortality in overlap patients.
摘要：
■睡眠对呼吸和气体交换具有重要影响，这可能对慢性阻塞性肺疾病（COPD）患者产生负面影响。COPD和阻塞性睡眠呼吸暂停（OSA）非常普遍，可能共存，这就是所谓的重叠综合症。
■OSA-COPD重叠的可能性代表了保护和促进因素的平衡，例如过度充气和液体潴留；因此，不同的COPD临床表型影响合并OSA的可能性.OSA-COPD重叠的临床表现是非特异性的，诊断需要临床意识来识别需要过夜研究的患者。COPD和OSA都与一系列重叠的生理和生物学紊乱有关，包括缺氧和炎症，这些紊乱会导致心血管合并症。OSA-COPD重叠患者的治疗与单纯COPD患者不同，接受气道正压通气（PAP）治疗的重叠患者的生存率优于未经治疗的患者。
■OSA-COPD重叠的认识具有重要的临床意义，因为它对结果和管理的影响。重叠的管理应解决睡眠质量和无序的气体交换。PAP治疗已证明COPD恶化的减少，住院治疗,重叠患者的医疗费用和死亡率。
■OSA-COPD重叠的可能性代表了保护和促进因素的平衡，例如过度充气和液体潴留；因此，不同的COPD临床表型影响合并OSA的可能性.OSA-COPD重叠的临床表现是非特异性的，诊断需要临床意识来识别需要过夜研究的患者。COPD和OSA都与一系列重叠的生理和生物学紊乱有关，包括缺氧和炎症，这些紊乱会导致心血管合并症。OSA-COPD重叠患者的治疗与单纯COPD患者不同，接受气道正压通气（PAP）治疗的重叠患者的生存率优于未经治疗的患者。
■OSA-COPD重叠的认识具有重要的临床意义，因为它对结果和管理的影响。重叠的管理应解决睡眠质量和无序的气体交换。PAP治疗已证明COPD恶化的减少，住院治疗,重叠患者的医疗费用和死亡率。
