关键词: Centrifugal blood pump Hemolysis prediction Multiphase flow Numerical simulation

Mesh : Hemolysis Humans Heart-Assist Devices / adverse effects Stress, Mechanical Equipment Design Erythrocytes / cytology Centrifugation Computer Simulation

来  源:   DOI:10.7507/1001-5515.202311015   PDF(Pubmed)

Abstract:
Red blood cells are destroyed when the shear stress in the blood pump exceeds a threshold, which in turn triggers hemolysis in the patient. The impeller design of centrifugal blood pumps significantly influences the hydraulic characteristics and hemolytic properties of these devices. Based on this premise, the present study employs a multiphase flow approach to numerically simulate centrifugal blood pumps, investigating the performance of pumps with varying numbers of blades and blade deflection angles. This analysis encompassed the examination of flow field characteristics, hydraulic performance, and hemolytic potential. Numerical results indicated that the concentration of red blood cells and elevated shear stresses primarily occurred at the impeller and volute tongue, which drastically increased the risk of hemolysis in these areas. It was found that increasing the number of blades within a certain range enhanced the hydraulic performance of the pump but also raised the potential for hemolysis. Moreover, augmenting the blade deflection angle could improve the hemolytic performance, particularly in pumps with a higher number of blades. The findings from this study can provide valuable insights for the structural improvement and performance enhancement of centrifugal blood pumps.
血泵中剪切应力超过阈值时红细胞会被破坏,进而引发患者出现溶血。离心式血泵叶轮结构设计对血泵的水力特性及溶血特性有着显著影响。基于此,本文采用多相流方法对离心式血泵进行数值模拟,探究了具有不同叶片数量及偏转角叶轮形式血泵的性能,分析了血泵的流场特性、水力性能以及溶血性能。数值模拟结果表明:血泵主要在叶轮及隔舌处出现了红细胞集聚现象及较大的切应力,导致此处溶血急剧增加;在一定范围内增加叶片数会提升血泵水力性能,同时也会增加溶血风险;增加叶片偏转角有助于提升血泵溶血性能,在叶片数较多时更为明显。本文研究结果可为离心式血泵的结构改进及性能改善提供参考。.
摘要:
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