Abstract：
BACKGROUND: The information relating to the outcome specifically for juvenile dogs with meningoencephalitis of unknown etiology (MUE) is lacking.
OBJECTIVE: To describe the clinical presentation, diagnostic findings, treatment, and outcome in a cohort of dogs with MUE <52 weeks old.
METHODS: Thirty-four client-owned dogs.
METHODS: Multicenter retrospective case series. Records from 5 referral centers were searched. Data was extracted from the medical records and referring veterinarians were contacted for survival data if this was not available from the record.
RESULTS: The mean age was 31 weeks; the youngest dog was 11 weeks and 3 dogs were <16 weeks old. Altered mentation (71%), ataxia (44%), seizures (29%), and circling (26%) were the most common presenting complaints. Neuroanatomical localization was to the forebrain (38%), multifocal (35%), brainstem (18%), and cerebellum (12%). Corticosteroid monotherapy (n = 15) and corticosteroid plus cytosine arabinoside (n = 15) were used in equal proportions. Outcome data was available for 26 dogs, 8 (31%) were alive at the time of data collection with a follow-up range of 135 to 2944 days. Death or euthanasia was related to MUE in 17/18 dogs that died during the study period. Kaplan-Meier survival analysis demonstrated a median survival time for all-cause death of 84 days.
CONCLUSIONS: The prognosis for MUE in this subset of dogs was considered poor.
OBJECTIVE: To describe the clinical presentation, diagnostic findings, treatment, and outcome in a cohort of dogs with MUE <52 weeks old.
METHODS: Thirty-four client-owned dogs.
METHODS: Multicenter retrospective case series. Records from 5 referral centers were searched. Data was extracted from the medical records and referring veterinarians were contacted for survival data if this was not available from the record.
RESULTS: The mean age was 31 weeks; the youngest dog was 11 weeks and 3 dogs were <16 weeks old. Altered mentation (71%), ataxia (44%), seizures (29%), and circling (26%) were the most common presenting complaints. Neuroanatomical localization was to the forebrain (38%), multifocal (35%), brainstem (18%), and cerebellum (12%). Corticosteroid monotherapy (n = 15) and corticosteroid plus cytosine arabinoside (n = 15) were used in equal proportions. Outcome data was available for 26 dogs, 8 (31%) were alive at the time of data collection with a follow-up range of 135 to 2944 days. Death or euthanasia was related to MUE in 17/18 dogs that died during the study period. Kaplan-Meier survival analysis demonstrated a median survival time for all-cause death of 84 days.
CONCLUSIONS: The prognosis for MUE in this subset of dogs was considered poor.
摘要：
背景：缺乏与病因不明的脑膜脑炎（MUE）幼犬的结局有关的信息。
目的：描述临床表现，诊断结果，治疗,和结果在MUE<52周龄的狗队列中。
方法：34只客户拥有的狗。
方法：多中心回顾性病例系列。检索了5个转诊中心的记录。从医疗记录中提取数据，如果无法从记录中获得生存数据，则联系转诊的兽医。
结果：平均年龄为31周；最小的狗为11周，3只狗<16周大。改变状态（71%），共济失调（44%），缉获量(29%)，和盘旋(26%)是最常见的投诉。神经解剖定位在前脑（38%），多焦（35%），脑干（18%），和小脑（12%）。以相等比例使用皮质类固醇单一疗法（n=15）和皮质类固醇加胞嘧啶阿拉伯糖苷（n=15）。有26只狗的结果数据，8（31％）在数据收集时存活，随访范围为135至2944天。在研究期间死亡的17/18只狗中，死亡或安乐死与MUE有关。Kaplan-Meier生存分析显示全因死亡的中位生存时间为84天。
结论：该亚组犬的MUE预后较差。
目的：描述临床表现，诊断结果，治疗,和结果在MUE<52周龄的狗队列中。
方法：34只客户拥有的狗。
方法：多中心回顾性病例系列。检索了5个转诊中心的记录。从医疗记录中提取数据，如果无法从记录中获得生存数据，则联系转诊的兽医。
结果：平均年龄为31周；最小的狗为11周，3只狗<16周大。改变状态（71%），共济失调（44%），缉获量(29%)，和盘旋(26%)是最常见的投诉。神经解剖定位在前脑（38%），多焦（35%），脑干（18%），和小脑（12%）。以相等比例使用皮质类固醇单一疗法（n=15）和皮质类固醇加胞嘧啶阿拉伯糖苷（n=15）。有26只狗的结果数据，8（31％）在数据收集时存活，随访范围为135至2944天。在研究期间死亡的17/18只狗中，死亡或安乐死与MUE有关。Kaplan-Meier生存分析显示全因死亡的中位生存时间为84天。
结论：该亚组犬的MUE预后较差。
