PDF(Pubmed)
Abstract：
BACKGROUND: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.
OBJECTIVE: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).
METHODS: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.
RESULTS: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants\' assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.
CONCLUSIONS: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.
OBJECTIVE: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).
METHODS: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.
RESULTS: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants\' assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.
CONCLUSIONS: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.
摘要：
背景：精致的眶周区域容易发生皮肤脱水，皱纹,失去弹性。因此，针对眶周区需要有针对性的有效抗衰老干预措施.
目的：为了评估用活性复合物（酵母/大米发酵滤液，N-乙酰神经氨酸,棕榈酰三肽-1和棕榈酰四肽-7）。
方法:使用人皮肤成纤维细胞模型评估活性复合物的细胞活力和关键细胞外基质(ECM)组分的表达。在为期12周的临床试验中,皮肤水合作用,弹性,面部照片,眼霜应用后的胶原蛋白密度使用角膜测量仪进行评估，切削计,VISIA,和超声波装置，分别。皮肤科医生和参与者在基线时评估临床疗效和安全性，4、8和12周后。
结果：PCR和免疫荧光分析表明，活性复合物显着刺激成纤维细胞增殖（p<0.05），并显着促进胶原蛋白和弹性蛋白的合成。临床表现显示皮肤水合作用显著增强(28.12%),弹性(18.81%)，和胶原蛋白生产（54.99％）后12周的眼霜应用。皮肤病学评估和参与者评估报告皮肤水分显著改善，粗糙度,弹性,以及第8周的细纹和皱纹。
结论：新型抗衰老眼霜，富含活性复合物，展示了全面的振兴效果，有效解决轨道周围区域的老龄化问题，加上高度的安全形象。
目的：为了评估用活性复合物（酵母/大米发酵滤液，N-乙酰神经氨酸,棕榈酰三肽-1和棕榈酰四肽-7）。
方法:使用人皮肤成纤维细胞模型评估活性复合物的细胞活力和关键细胞外基质(ECM)组分的表达。在为期12周的临床试验中,皮肤水合作用,弹性,面部照片,眼霜应用后的胶原蛋白密度使用角膜测量仪进行评估，切削计,VISIA,和超声波装置，分别。皮肤科医生和参与者在基线时评估临床疗效和安全性，4、8和12周后。
结果：PCR和免疫荧光分析表明，活性复合物显着刺激成纤维细胞增殖（p<0.05），并显着促进胶原蛋白和弹性蛋白的合成。临床表现显示皮肤水合作用显著增强(28.12%),弹性(18.81%)，和胶原蛋白生产（54.99％）后12周的眼霜应用。皮肤病学评估和参与者评估报告皮肤水分显著改善，粗糙度,弹性,以及第8周的细纹和皱纹。
结论：新型抗衰老眼霜，富含活性复合物，展示了全面的振兴效果，有效解决轨道周围区域的老龄化问题，加上高度的安全形象。
