PDF(Pubmed)
Abstract：
BACKGROUND: The impact of mRNA COVID-19 vaccines on the immunological profiles of pregnant women remains a crucial area of study. This research aims to explore the specific immunological changes triggered by these vaccines in this demographic.
METHODS: In a focused investigation, we examined the effects of mRNA COVID-19 vaccination on microRNA expression in pregnant women. Key microRNAs, including miR-451a, miR-23a-3p, and miR-21-5p, were analyzed for expression changes post-vaccination. Additionally, we assessed variations in S1RBD IgG levels and specific cytokines to gauge the broader immunological response.
RESULTS: Post-vaccination, significant expression shifts in the targeted microRNAs were observed. Alongside these changes, we noted alterations in S1RBD IgG and various cytokines, indicating an adapted inflammatory response. Notably, these immunological markers displayed no direct correlation with S1RBD IgG concentrations, suggesting a complex interaction between the vaccine and the immune system in pregnant women.
CONCLUSIONS: Our pilot study provides valuable insights into the nuanced effects of the mRNA COVID-19 vaccine on immune dynamics in pregnant women, particularly emphasizing the role of microRNAs. The findings illuminate the intricate interplay between vaccines, microRNAs, and immune responses, enhancing our understanding of these relationships in the context of pregnancy. This research contributes significantly to the growing body of knowledge regarding mRNA COVID-19 vaccines and their specific impact on maternal immunology, offering a foundation for further studies in this vital area.
METHODS: In a focused investigation, we examined the effects of mRNA COVID-19 vaccination on microRNA expression in pregnant women. Key microRNAs, including miR-451a, miR-23a-3p, and miR-21-5p, were analyzed for expression changes post-vaccination. Additionally, we assessed variations in S1RBD IgG levels and specific cytokines to gauge the broader immunological response.
RESULTS: Post-vaccination, significant expression shifts in the targeted microRNAs were observed. Alongside these changes, we noted alterations in S1RBD IgG and various cytokines, indicating an adapted inflammatory response. Notably, these immunological markers displayed no direct correlation with S1RBD IgG concentrations, suggesting a complex interaction between the vaccine and the immune system in pregnant women.
CONCLUSIONS: Our pilot study provides valuable insights into the nuanced effects of the mRNA COVID-19 vaccine on immune dynamics in pregnant women, particularly emphasizing the role of microRNAs. The findings illuminate the intricate interplay between vaccines, microRNAs, and immune responses, enhancing our understanding of these relationships in the context of pregnancy. This research contributes significantly to the growing body of knowledge regarding mRNA COVID-19 vaccines and their specific impact on maternal immunology, offering a foundation for further studies in this vital area.
摘要：
背景：COVID-19mRNA疫苗对孕妇免疫特征的影响仍然是一个关键的研究领域。这项研究旨在探索这些疫苗在这种人口统计学中引发的特定免疫学变化。
方法：在集中调查中，我们研究了COVID-19mRNA疫苗接种对孕妇microRNA表达的影响.关键microRNAs,包括miR-451a，miR-23a-3p,和miR-21-5p，分析疫苗接种后的表达变化。此外,我们评估了S1RBDIgG水平和特异性细胞因子的变化,以评估更广泛的免疫应答.
结果：疫苗接种后，在靶向的microRNA中观察到显著的表达变化。伴随着这些变化,我们注意到S1RBDIgG和各种细胞因子的变化，表明适应的炎症反应。值得注意的是,这些免疫标记与S1RBDIgG浓度没有直接相关性，提示孕妇的疫苗和免疫系统之间存在复杂的相互作用。
结论：我们的初步研究为COVID-19mRNA疫苗对孕妇免疫动力学的细微影响提供了有价值的见解，特别强调microRNA的作用。这些发现阐明了疫苗之间复杂的相互作用，microRNAs,和免疫反应，加强我们在怀孕背景下对这些关系的理解。这项研究极大地促进了有关COVID-19mRNA疫苗及其对母体免疫学的特定影响的知识的增长，为这一重要领域的进一步研究奠定了基础。
方法：在集中调查中，我们研究了COVID-19mRNA疫苗接种对孕妇microRNA表达的影响.关键microRNAs,包括miR-451a，miR-23a-3p,和miR-21-5p，分析疫苗接种后的表达变化。此外,我们评估了S1RBDIgG水平和特异性细胞因子的变化,以评估更广泛的免疫应答.
结果：疫苗接种后，在靶向的microRNA中观察到显著的表达变化。伴随着这些变化,我们注意到S1RBDIgG和各种细胞因子的变化，表明适应的炎症反应。值得注意的是,这些免疫标记与S1RBDIgG浓度没有直接相关性，提示孕妇的疫苗和免疫系统之间存在复杂的相互作用。
结论：我们的初步研究为COVID-19mRNA疫苗对孕妇免疫动力学的细微影响提供了有价值的见解，特别强调microRNA的作用。这些发现阐明了疫苗之间复杂的相互作用，microRNAs,和免疫反应，加强我们在怀孕背景下对这些关系的理解。这项研究极大地促进了有关COVID-19mRNA疫苗及其对母体免疫学的特定影响的知识的增长，为这一重要领域的进一步研究奠定了基础。
