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Abstract：
Understanding the underlying mechanisms of HIV pathogenesis is critical for designing successful HIV vaccines and cure strategies. However, achieving this goal is complicated by the virus\'s direct interactions with immune cells, the induction of persistent reservoirs in the immune system cells, and multiple strategies developed by the virus for immune evasion. Meanwhile, HIV and SIV infections induce a pandysfunction of the immune cell populations, making it difficult to untangle the various concurrent mechanisms of HIV pathogenesis. Over the years, one of the most successful approaches for dissecting the immune correlates of protection in HIV/SIV infection has been the in vivo depletion of various immune cell populations and assessment of the impact of these depletions on the outcome of infection in non-human primate models. Here, we present a detailed analysis of the strategies and results of manipulating SIV pathogenesis through in vivo depletions of key immune cells populations. Although each of these methods has its limitations, they have all contributed to our understanding of key pathogenic pathways in HIV/SIV infection.
摘要：
了解HIV发病机理的潜在机制对于设计成功的HIV疫苗和治愈策略至关重要。然而,病毒与免疫细胞的直接相互作用使实现这一目标变得复杂，免疫系统细胞中持久性储库的诱导，以及病毒开发的多种免疫逃避策略。同时,HIV和SIV感染诱导免疫细胞群的功能广泛，这使得很难解开HIV发病机制的各种并发机制。多年来,在HIV/SIV感染中,最成功的方法之一是体内消耗各种免疫细胞群,并评估这些消耗对非人灵长类动物模型感染结果的影响.这里,我们详细分析了通过关键免疫细胞群的体内消耗来操纵SIV发病机制的策略和结果.尽管这些方法都有其局限性，它们都有助于我们了解HIV/SIV感染的关键致病途径.
