PDF(Pubmed)
Abstract：
Brazil has earned the moniker \"arbovirus hotspot\", providing an ideal breeding ground for a multitude of arboviruses thriving in various zoonotic and urban cycles. As the planet warms and vectors expand their habitat range, a nuanced understanding of lesser-known arboviruses and the factors that could drive their emergence becomes imperative. Among these viruses is the Iguape virus (IGUV), a member of the Orthoflavivirus aroaense species, which was first isolated in 1979 from a sentinel mouse in the municipality of Iguape, within the Vale do Ribeira region of São Paulo State. While evidence suggests that IGUV circulates among birds, wild rodents, marsupials, bats, and domestic birds, there is no information available on its pathogenesis in both humans and animals. The existing literature on IGUV spans decades, is outdated, and is often challenging to access. In this review, we have curated information from the known literature, clarifying its elusive nature and investigating the factors that may influence its emergence. As an orthoflavivirus, IGUV poses a potential threat, which demands our attention and vigilance, considering the serious outbreaks that the Zika virus, another neglected orthoflavivirus, has unleashed in the recent past.
摘要：
巴西赢得了“虫媒病毒热点”的绰号，为在各种人畜共患病和城市周期中繁衍的多种虫媒病毒提供了理想的繁殖地。随着行星变暖和媒介扩大它们的栖息地范围，对鲜为人知的虫媒病毒以及可能导致其出现的因素进行细微差别的理解变得势在必行。这些病毒中有Iguape病毒（IGUV），正黄病毒属阿拉伯物种的成员，它于1979年首次从伊瓜佩市的前哨老鼠中分离出来，在圣保罗州的ValedoRibeira地区。虽然有证据表明IGUV在鸟类中循环，野生啮齿动物,有袋动物,蝙蝠,和家禽，在人类和动物中都没有关于其发病机理的信息。关于IGUV的现有文献跨越了几十年，已经过时了,并且通常具有挑战性。在这次审查中,我们从已知的文献中收集了信息，澄清其难以捉摸的性质，并调查可能影响其出现的因素。作为一种正黄病毒，IGUV构成潜在威胁,这需要我们的关注和警惕，考虑到寨卡病毒的严重爆发，另一种被忽视的正黄病毒，在最近的过去释放。
