PDF(Pubmed)
Abstract：
Pentasilver hexaoxoiodate (Ag5IO6) has broad-spectrum antimicrobial efficacy, including the long-term prevention of microbial adherence, the rapid killing of planktonic microorganisms, and the elimination of mature biofilms. This study\'s goal was to determine whether it may also have antiviral activity against structurally distinct viruses. Ag5IO6 was tested following ASTM E1052-20, Standard Practice to Assess the Activity of Microbicides Against Viruses in Suspension, against adenovirus type 5, murine norovirus, poliovirus type 1, SARS-CoV-2 (original), and SARS-CoV-2 (omicron) (host cells: H1HeLa, RAW 264.7, LLC-MK2, Vero E6, and Vero E6, respectively). A 0.1 g/mL Ag5IO6 suspension was prepared and the viruses were exposed for 30 min, 4 h, or 24 h. Exposure to Ag5IO6 resulted in complete kill of SARS-CoV-2 (omicron) within 30 min, as well as complete kill of both SARS-CoV-2 (original) and the murine norovirus within 4 h. Ag5IO6 showed increasing activity over time against the adenovirus, but did not achieve a 3-log reduction within 24 h, and showed no antiviral activity against the poliovirus. These results demonstrate that Ag5IO6 has antiviral activity against medically important viruses, in addition to its well-characterized antimicrobial activity, suggesting that it may be valuable in situations where the prevention or simultaneous treatment of microbes and viruses are necessary.
摘要：
Pentasilver六氧碘酸盐（Ag5IO6）具有广谱抗菌功效，包括长期预防微生物粘附，快速杀死浮游微生物，和消除成熟的生物膜。这项研究的目的是确定它是否也可能对结构不同的病毒具有抗病毒活性。Ag5IO6按照ASTME1052-20，评估悬浮液中的杀微生物剂对病毒的活性的标准操作规程进行测试。对抗腺病毒5型，鼠诺如病毒，脊髓灰质炎病毒1型，SARS-CoV-2（原始），和SARS-CoV-2（omicron）（宿主细胞：H1HeLa，RAW264.7，LLC-MK2，VeroE6和VeroE6分别）。制备0.1g/mL的Ag5IO6悬浮液，并将病毒暴露30分钟，4h,或24小时。暴露于Ag5IO6导致SARS-CoV-2（omicron）在30分钟内完全杀死，以及在4小时内完全杀死SARS-CoV-2（原始）和鼠诺如病毒。Ag5IO6对腺病毒的活性随着时间的推移而增加，但在24小时内没有达到3-log的减少，对脊髓灰质炎病毒没有抗病毒活性。这些结果表明，Ag5IO6对医学上重要的病毒具有抗病毒活性，除了其良好的抗菌活性，这表明它在需要预防或同时治疗微生物和病毒的情况下可能是有价值的。
