PDF(Pubmed)
Abstract：
Influenza A viruses continue to be a serious health risk to people and result in a large-scale socio-economic loss. Avian influenza viruses typically do not replicate efficiently in mammals, but through the accumulation of mutations or genetic reassortment, they can overcome interspecies barriers, adapt to new hosts, and spread among them. Zoonotic influenza A viruses sporadically infect humans and exhibit limited human-to-human transmission. However, further adaptation of these viruses to humans may result in airborne transmissible viruses with pandemic potential. Therefore, we are beginning to understand genetic changes and mechanisms that may influence interspecific adaptation, cross-species transmission, and the pandemic potential of influenza A viruses. We also discuss the genetic and phenotypic traits associated with the airborne transmission of influenza A viruses in order to provide theoretical guidance for the surveillance of new strains with pandemic potential and the prevention of pandemics.
摘要：
甲型流感病毒继续对人们造成严重的健康风险，并导致大规模的社会经济损失。禽流感病毒通常不能在哺乳动物中有效复制，但是通过突变或基因重组的积累，它们可以克服种间的障碍，适应新的主机，在他们中间传播。人畜共患甲型流感病毒偶尔感染人类，并表现出有限的人与人之间的传播。然而,这些病毒进一步适应人类可能导致具有大流行潜力的空气传播病毒。因此,我们开始了解可能影响种间适应的遗传变化和机制，跨物种传播，以及甲型流感病毒的大流行潜力。我们还讨论了与甲型流感病毒空气传播相关的遗传和表型特征，以期为监测具有大流行潜力的新毒株和预防大流行提供理论指导。
