PDF(Pubmed)
Abstract：
In this study, an improved PVA/PLA fibrous hemostatic membrane was prepared by electrospinning technology combined with air plasma modification. The plasma treatment was used to modify PLA to enhance the interlayer bonding between the PVA and PLA fibrous membranes first, then modify the PVA to improve the hemostatic capacity. The surfaces of the PLA and PVA were oxidized after air plasma treatment, the fibrous diameter was reduced, and roughness was increased. Plasma treatment enhanced the interfacial bond strength of PLA/PVA composite fibrous membrane, and PLA acted as a good mechanical support. Plasma-treated PVA/PLA composite membranes showed an increasing liquid-enrichment capacity of 350% and shortened the coagulation time to 258 s. The hemostatic model of the liver showed that the hemostatic ability of plasma-treated PVA/PLA composite membranes was enhanced by 79% compared to untreated PVA membranes, with a slight improvement over commercially available collagen. The results showed that the plasma-treated PVA/PLA fibers were able to achieve more effective hemostasis, which provides a new strategy for improving the hemostatic performance of hemostatic materials.
摘要：
在这项研究中,采用静电纺丝技术结合空气等离子体改性制备了一种改进的PVA/PLA纤维止血膜。首先采用等离子体处理对PLA进行改性,以增强PVA与PLA纤维膜之间的层间结合,然后改性PVA以提高止血能力。PLA和PVA的表面在空气等离子体处理后被氧化,纤维直径减小，粗糙度增加。等离子体处理提高了PLA/PVA复合纤维膜的界面结合强度,PLA起到了很好的机械支撑作用。经血浆处理的PVA/PLA复合膜显示出增加350％的液体富集能力，并将凝固时间缩短至258s。肝脏的止血模型显示，经血浆处理的PVA/PLA复合膜的止血能力比未经处理的PVA膜提高了79％，与市售胶原蛋白相比略有改善。结果表明,经等离子体处理的PVA/PLA纤维能够实现更有效的止血,为改善止血材料的止血性能提供了新的策略。
