PDF(Pubmed)
Abstract：
Enterococci spp. are Gram-positive bacteria that cause mild to severe infections, many associated with the oral cavity, such as periapical infections and healthcare-associated infections (HAIs). Many of these infections become serious diseases that are difficult to resolve, specifically when multidrug-resistant (MDR) strains cause them. In recent years, the number of MDR strains of Enterococcus spp. has increased significantly. This increased prevalence of MDR strains produces significant pressure to generate more antimicrobial therapies, but there is a decline in the production of new antibiotics, driving the development of complementary therapies, such as photodynamic therapy (PDT). PDT combines a photosensitizer agent (PS), light, and oxygen to cause photooxidative stress in bacterial cells. PDT can eradicate Enterococcus spp. contaminations, improve the classic cleaning processes, and eradicate the bacteria in dental pieces. PDT\'s effectiveness can be improved with nanoparticles that function as carriers. Our work aims to describe the advances in PDT against Enterococcus spp. as a complement to antibiotic therapy, focusing on infections by Enterococcus faecium and Enterococcus faecalis, dental hygiene, and using nanoparticles to improve the antimicrobial effect. A systematic bibliographic search without a meta-analysis was conducted on various databases, using inclusion and exclusion criteria to identify the most relevant research. Of the 193 non-redundant articles found, 65 were selected for a systematic review, from which a summary table was created and a manual description was made. Photodynamic therapy for treating E. faecium and E. faecalis is a widely studied area, with promising results concerning bactericidal effectiveness and reductions in biofilm formation, particularly in regard to dental hygiene. Because most of the studies were conducted in vitro or ex vivo, the results indicated that there were not sufficient data to initiate clinical trials for safety and efficacy studies on humans.
摘要：
肠球菌属。是革兰氏阳性细菌，会引起轻度到严重的感染，许多与口腔有关的，如根尖周感染和医疗保健相关感染（HAIs）。这些感染中的许多成为难以解决的严重疾病，特别是当多重耐药（MDR）菌株引起它们时。近年来,肠球菌的MDR菌株数量。显著增加。MDR菌株患病率的增加产生了产生更多抗菌疗法的巨大压力。但是新抗生素的产量下降了，推动辅助疗法的发展，例如光动力疗法(PDT)。PDT结合光敏剂（PS），光,和氧气在细菌细胞中引起光氧化应激。PDT可以根除肠球菌。污染,改进经典的清洁过程，并根除牙片中的细菌。使用作为载体的纳米颗粒可以提高PDT的有效性。我们的工作旨在描述PDT对肠球菌属的研究进展。作为抗生素治疗的补充，重点是屎肠球菌和粪肠球菌的感染，牙齿卫生,并使用纳米颗粒来提高抗菌效果。在没有荟萃分析的情况下，对各种数据库进行了系统的书目搜索，使用纳入和排除标准来确定最相关的研究。在发现的193篇非冗余文章中，65人被选中进行系统审查，从中创建了一个汇总表，并进行了手动描述。光动力疗法治疗屎肠球菌和粪肠球菌是一个广泛研究的领域，有关杀菌效果和减少生物膜形成的有希望的结果，特别是在牙齿卫生方面。因为大多数研究是在体外或离体进行的，结果表明，没有足够的数据来启动人体安全性和有效性研究的临床试验。
