PDF(Pubmed)
Abstract：
Cell mechanics is gaining attraction in drug screening, but the applicable methods have not yet become part of the standardized norm. This review presents the current state of the art for atomic force microscopy, which is the most widely available method. The field is first motivated as a new way of tracking pharmaceutical effects, followed by a basic introduction targeted at pharmacists on how to measure cellular stiffness. The review then moves on to the current state of the knowledge in terms of experimental results and supplementary methods such as fluorescence microscopy that can give relevant additional information. Finally, rheological approaches as well as the theoretical interpretations are presented before ending on additional methods and outlooks.
摘要：
细胞力学在药物筛选中获得了吸引力，但是适用的方法尚未成为标准化规范的一部分。这篇综述介绍了原子力显微镜的最新技术，这是最广泛使用的方法。该领域首先被认为是一种追踪药物效果的新方法，随后是针对药剂师如何测量细胞硬度的基本介绍。然后，在实验结果和补充方法方面，如荧光显微镜，可以提供相关的额外信息，审查移动到知识的当前状态。最后,在结束其他方法和展望之前，提出了流变方法和理论解释。
