PDF(Pubmed)
Abstract：
This review paper examines the evolution of photodynamic therapy (PDT) as a novel, minimally invasive strategy for treating atherosclerosis, a leading global health concern. Atherosclerosis is characterized by the accumulation of lipids and inflammation within arterial walls, leading to significant morbidity and mortality through cardiovascular diseases such as myocardial infarction and stroke. Traditional therapeutic approaches have primarily focused on modulating risk factors such as hypertension and hyperlipidemia, with emerging evidence highlighting the pivotal role of inflammation. PDT, leveraging a photosensitizer, specific-wavelength light, and oxygen, offers targeted treatment by inducing cell death in diseased tissues while sparing healthy ones. This specificity, combined with advancements in nanoparticle technology for improved delivery, positions PDT as a promising alternative to traditional interventions. The review explores the mechanistic basis of PDT, its efficacy in preclinical studies, and the potential for enhancing plaque stability and reducing macrophage density within plaques. It also addresses the need for further research to optimize treatment parameters, mitigate adverse effects, and validate long-term outcomes. By detailing past developments, current progress, and future directions, this paper aims to highlight PDT\'s potential in revolutionizing atherosclerosis treatment, bridging the gap from experimental research to clinical application.
摘要：
这篇综述论文探讨了光动力疗法(PDT)作为一种新型疗法的演变，动脉粥样硬化的微创治疗策略，全球领先的健康问题。动脉粥样硬化的特征是脂质和炎症在动脉壁内的积累，导致显著的发病率和死亡率，通过心血管疾病，如心肌梗塞和中风。传统的治疗方法主要集中在调节危险因素，如高血压和高脂血症，有新的证据强调炎症的关键作用。PDT,利用光敏剂，特定波长的光，和氧气,通过诱导患病组织中的细胞死亡同时保留健康组织来提供靶向治疗。这种特异性，结合纳米粒子技术的进步，以改善递送，将PDT定位为传统干预的有希望的替代方案。这篇综述探讨了PDT的机理基础，其在临床前研究中的功效，以及增强斑块稳定性和降低斑块内巨噬细胞密度的潜力。它还解决了进一步研究以优化治疗参数的需要，减轻不利影响，并验证长期结果。通过详细描述过去的发展，目前的进展,和未来的方向，本文旨在强调PDT在彻底改变动脉粥样硬化治疗方面的潜力，弥合从实验研究到临床应用的差距。
