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Abstract：
This study explores developing and optimizing a nanoemulsion (NE) system loaded with dipyridamole and roflumilast, aiming to improve skin penetration and retention. The NE formulation was further transformed into a nanoemulgel to enhance its application as a topical treatment for psoriasis. Solubility studies were conducted to select the oil, surfactant, and co-surfactant. Phase diagrams were constructed using the aqueous phase titration method. All the formulations were in nanoscale, and Formula (F2) (which contains oleic acid oil as the oil phase, a mixture of Surfactant Tween 80 and co-surfactant (ethanol) at a ratio of 1:2 in addition to distilled water as an aqueous phase in a ratio of 1:5:4, respectively) was the selected formula depending on the particle size, PDI, and zeta potential. Formula (F2) has the best ratio because it gives the smallest nanoemulsion globule size (particle size average of 167.1 nm), the best homogenicity (lowest PDI of 0.195), and the highest stability (higher zeta potential of -32.22). The selected formula was converted into a nanoemulgel by the addition of 0.5% (w/w) xanthan gum (average particle size of 172.7 nm) and the best homogenicity (lowest PDI of 0.121%) and highest stability (higher zeta potential of -28.31). In conclusion, the selected formula has accepted physical and chemical properties, which enhanced skin penetration.
摘要：
本研究探索开发和优化负载双嘧达莫和罗氟司特的纳米乳液（NE）系统，旨在改善皮肤渗透和保留。将NE制剂进一步转化为纳米乳液凝胶以增强其作为牛皮癣的局部治疗的应用。进行溶解度研究以选择油，表面活性剂，和助表面活性剂。使用水相滴定法构建相图。所有的配方都是纳米级的,和式（F2）（包含油酸油作为油相，除了以1:5:4的比例作为水相的蒸馏水之外，表面活性剂吐温80和助表面活性剂(乙醇)的比例为1:2的混合物)是根据粒度选择的配方，PDI,和zeta电位。配方（F2）具有最佳的比例，因为它给出了最小的纳米乳液球尺寸（平均粒径为167.1nm），最佳均匀性(最低PDI为0.195)，和最高的稳定性（较高的zeta电位-32.22）。通过添加0.5%(w/w)黄原胶(平均粒度为172.7nm)和最佳均一性(0.121%的最低PDI)和最高稳定性(-28.31的较高ζ电位),将所选配方转化成纳米乳液凝胶。总之,选定的配方具有公认的物理和化学性质，增强皮肤渗透。
