PDF(Pubmed)
Abstract：
Acne vulgaris is a common disease, which occurs in adolescents as well as adults and has a significant influence on the patient\'s quality of life (QoL) in every aspect. Due to resistance to standard therapies, it has become necessary to prospect for new treatment strategies. It is important to highlight that the diagnosis and treatment of the underlying cause of acne such as metabolic and hormonal disorders may significantly improve the effectiveness of acne treatment. The correlation between Insulin Resistance (IR) and acne has been proven. Both disorders share many common occurrence factors and activation pathways. Metformin, an antihyperglycemic agent, seems to be a possible therapy option, not only because of its insulin sensitizing ability but also via plenty of additional effects of this medicine. While the efficiency of metformin therapy in patients with acne and Polycystic Ovary Syndrome (PCOS) is well explored, it is still necessary to evaluate it in patients without any endocrinopathies. This meta-analysis aimed to estimate the effectiveness of oral metformin as a monotherapy in acne patients without PCOS or other endocrinopathies. Study selection was performed with included criteria such as no PCOS and other endocrinopathies diagnosed, oral administration of metformin, and metformin in monotherapy. Selected studies contained comparisons in the Global Acne Grading System (GAGS) before and after metformin therapy. Statistical analysis detected significant improvement in skin condition after treatment with metformin.
摘要：
寻常痤疮是一种常见病,这发生在青少年和成年人中，对患者的生活质量（QoL）在各个方面都有重大影响。由于对标准疗法的抵制，有必要展望新的治疗策略。重要的是要强调，诊断和治疗痤疮的根本原因，例如代谢和激素紊乱，可以显着提高痤疮治疗的有效性。胰岛素抵抗（IR）与痤疮之间的相关性已得到证实。两种疾病都有许多共同的发生因素和激活途径。二甲双胍,一种抗高血糖药,似乎是一种可能的治疗选择,不仅因为它的胰岛素增敏能力，而且还通过这种药物的大量附加作用。虽然二甲双胍治疗痤疮和多囊卵巢综合征（PCOS）患者的有效性得到了很好的探索，仍有必要对无任何内分泌疾病的患者进行评估。这项荟萃分析旨在评估口服二甲双胍作为单药治疗无PCOS或其他内分泌疾病的痤疮患者的有效性。根据纳入的标准进行研究选择，例如未诊断出PCOS和其他内分泌疾病，口服二甲双胍，和二甲双胍单药治疗。选定的研究包含二甲双胍治疗前后全球痤疮评分系统（GAGS）的比较。统计分析检测到二甲双胍治疗后皮肤状况的显着改善。
