PDF(Pubmed)
Abstract：
This study analyzed the overall quality of the diet using predefined indices, including the Healthy Eating Index-2015 (HEI-2015), the Alternative Healthy Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED) score, the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII®), to explore their association with the risk of bladder cancer in the Multiethnic Cohort Study. Data were taken from 186,979 African American, Japanese American, Latino, Native Hawaiian, and non-Hispanic White participants aged 45-75 years, with 1152 incident cases of invasive bladder cancer during a mean follow-up period of 19.2 ± 6.6 years. Cox models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with comprehensive adjustment for smoking. Comparing the highest vs. lowest diet quality score quintile, HRs (95% CIs) in men was 1.08 (0.86-1.36) for HEI-2015, 1.05 (0.84-1.30) for AHEI-2010, 1.01 (0.80-1.27) for aMED, 1.13 (0.90-1.41) for DASH, and 0.96 (0.76-1.21) for DII®, whereas the corresponding HRs for women were 0.75 (0.53-1.07), 0.64 (0.45-0.92), 0.60 (0.40-0.88), 0.66 (0.46-0.95), and 0.63 (0.43-0.90) with all p values for trend <0.05. The inverse association found in women did not vary by smoking status or race and ethnicity. Our findings suggest that adopting high-quality diets may reduce the risk of invasive bladder cancer among women in a multiethnic population.
摘要：
这项研究使用预定义的指标分析了饮食的整体质量，包括健康饮食指数-2015(HEI-2015)，替代健康饮食指数-2010(AHEI-2010)，替代地中海饮食（AMED）评分，停止高血压的饮食方法（DASH）评分，和膳食炎症指数(DII®)，在多种族队列研究中探讨它们与膀胱癌风险的关系。数据来自186,979名非洲裔美国人，日裔美国人,拉丁裔,夏威夷原住民,45-75岁的非西班牙裔白人参与者，在平均19.2±6.6年的随访期间，发生了1152例浸润性膀胱癌。Cox模型用于计算风险比（HR）和95％置信区间（CI），并对吸烟进行综合调整。比较最高的与最低的饮食质量得分五分之一，HEI-2015男性的HR（95％CI）为1.08（0.86-1.36），AHEI-2010为1.05（0.84-1.30），aMED为1.01（0.80-1.27），1.13（0.90-1.41）对于DASH，DII®为0.96（0.76-1.21），而女性的相应HR为0.75（0.53-1.07），0.64（0.45-0.92），0.60（0.40-0.88），0.66（0.46-0.95），和0.63(0.43-0.90)，所有p值趋势<0.05。在女性中发现的反向关联并不因吸烟状况或种族和种族而异。我们的发现表明，采用高质量的饮食可以降低多种族人群中女性患浸润性膀胱癌的风险。
