PDF(Pubmed)
Abstract：
Sprout ginseng extract (ThinkGIN™) manufactured through a smart farm system has been shown to improve memory in preclinical studies. This study conducted a 12-week randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of ThinkGIN™ for improving memory in subjective memory impairment (SMI). Subjects aged 55 to 75 years with SMI participated in this study. A total of 80 subjects who met the inclusion/exclusion criteria were assigned to the ThinkGIN™ group (n = 40, 450 mg ThinkGIN™/day) or a placebo group (n = 40). Efficacy and safety evaluations were conducted before intervention and at 12 weeks after intervention. As a result of 12 weeks of ThinkGIN™ intake, significant differences in SVLT, RCFT, MoCA-K, PSQI-K, and AChE were observed between the two groups. Safety evaluation (AEs, laboratory tests, vital signs, and electrocardiogram) revealed that ThinkGIN™ was safe with no clinically significant changes. Therefore, ThinkGIN™ has the potential to be used as a functional food to improve memory.
摘要：
通过智能农场系统生产的发芽人参提取物（ThinkGIN™）已被证明可以改善临床前研究中的记忆力。这项研究进行了为期12周的随机，双盲,安慰剂对照临床试验，以评估ThinkGIN™改善主观记忆障碍（SMI）记忆的有效性和安全性。年龄在55至75岁的SMI受试者参与了这项研究。将符合纳入/排除标准的总共80名受试者分配到ThinkGIN™组(n=40,450mgThinkGIN™/天)或安慰剂组(n=40)。在干预前和干预后12周进行疗效和安全性评价。由于12周的ThinkGIN™摄入，SVLT的显著差异，RCFT,MoCA-K,PSQI-K,观察两组的AChE。安全评价(AE，实验室测试,生命体征,和心电图）显示ThinkGIN™是安全的，没有临床显着变化。因此,ThinkGIN™具有被用作改善记忆力的功能性食物的潜力。
